Product Name
BAP1, cDNA Clone
Full Product Name
BAP1 cDNA Clone
Product Gene Name
BAP1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaataagg gctggctgga gctggagagc gacccaggcc tcttcaccct gctcgtggaa gatttcggtg tcaagggggt gcaagtggag gagatctacg accttcagag caaatgtcag ggccctgtat atggatttat cttcctgttc aaatggatcg aagagcgccg gtcccggcga aaggtctcta ccttggtgga tgatacgtcc gtgattgatg atgatattgt gaataacatg ttctttgccc accagctgat acccaactct tgtgcaactc atgccttgct gagcgtgctc ctgaactgca gcagcgtgga cctgggaccc accctgagtc gcatgaagga cttcaccaag ggttttagcc ctgagagcaa aggatatgcg attggcaatg ccccggagtt ggccaaggcc cataatagcc atgccaggcc cgagccacgc cacctccctg agaagcagaa tggccttagt gcagtgcgga ccatggaggc gttccacttt gtcagctatg tgcctatcac aggccggctc tttgagctgg atgggctgaa ggtctacccc attgaccatg ggccctgggg ggaggacgag gagtggacag acaaggcccg gcgggtcatc atggagcgta tcggcctcgc cactgcaggg gagccctacc acgacatccg cttcaacctg atggcagtgg tgcccgaccg caggatcaag tatgaggcca ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga ggctctgcag cagctgataa gagtaacaca gccagagctg attcagaccc acaagtctca agagtcacag ctgcctgagg agtccaagtc agccagcaac aagtccccgc tggtgctgga agcaaacagg gcccctgcag cctctgaggg caaccacaca gatggtgcag aggaggcggc tggttcatgc gcacaagccc catcccacag ccctcccaac aaacccaagc tagtggtgaa gcctccaggc agcagcctca atggggttca ccccaacccc actcccattg tccagcggct gccggccttt ctagacaatc acaattatgc caagtccccc atgcaggagg aagaagacct ggcggcaggt gtgggccgca gccgagttcc agtccgccca ccccagcagt actcagatga tgaggatgac tatgaggatg acgaggagga tgacgtgcag aacaccaact ctgcccttag gtataagggg aagggaacag ggaagccagg ggcattgagc ggttctgctg atgggcaact gtcagtgctg cagcccaaca ccatcaacgt cttggctgag aagctcaaag agtcccagaa ggacctctca attcctctgt ccatcaagac tagcagcggg gctgggagtc cggctgtggc agtgcccaca cactcgcagc cctcacccac ccccagcaat gagagtacag acacggcctc tgagatcggc agtgctttca actcgccact gcgctcgcct atccgctcag ccaacccgac gcggccctcc agccctgtca cctcccacat ctccaaggtg ctttttggag aggatgacag cctgctgcgt gttgactgca tacgctacaa ccgtgctgtc cgtgatctgg gtcctgtcat cagcacaggc ctgctgcacc tggctgagga tggggtgctg agtcccctgg cgctgacaga gggtgggaag ggttcctcgc cctccatcag accaatccaa ggcagccagg ggtccagcag cccagtggag aaggaggtcg tggaagccac ggacagcaga gagaagacgg ggatggtgag gcctggcgag cccttgagtg gggagaaata ctcacccaag gagctgctgg cactgctgaa gtgtgtggag gctgagattg caaactatga ggcgtgcctc aaggaggagg tagagaagag gaagaagttc aagattgatg accagagaag gacccacaac tacgatgagt tcatctgcac ctttatctcc atgctggctc aggaaggcat gctggccaac ctagtggagc agaacatctc cgtgcggcgg cgccaagggg tcagcatcgg ccggctccac aagcagcgga agcctgaccg gcggaaacgc tctcgcccct acaaggccaa gcgccagtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BAP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BAP1. It may not necessarily be applicable to this product.
NCBI Accession #
BC001596
[Other Products]
UniProt Secondary Accession #
Q6LEM0; Q7Z5E8; A8K993[Other Products]
UniProt Related Accession #
Q92560[Other Products]
Molecular Weight
80,362 Da
NCBI Official Full Name
Homo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), mRNA
NCBI Official Synonym Full Names
BRCA1 associated protein 1
NCBI Official Symbol
BAP1 [Similar Products]
NCBI Official Synonym Symbols
UCHL2; hucep-6; HUCEP-13
[Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase BAP1
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase BAP1
UniProt Synonym Protein Names
BRCA1-associated protein 1; Cerebral protein 6
Protein Family
BON1-associated protein
UniProt Gene Name
BAP1 [Similar Products]
UniProt Synonym Gene Names
KIAA0272 [Similar Products]
UniProt Entry Name
BAP1_HUMAN
NCBI Summary for BAP1
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
UniProt Comments for BAP1
BAP1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily.
Protein type: Tumor suppressor; Ubiquitin conjugating system; Protease; Ubiquitin-specific protease; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: chromatin binding; protein binding; ubiquitin-specific protease activity
Biological Process: negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; regulation of cell growth
Disease: Tumor Predisposition Syndrome
Research Articles on BAP1
1. loss of BAP1 expression can be used to very strongly support a pathological diagnosis of abdominal mesothelioma over serous carcinoma
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
