Product Name
AADACL1, Polyclonal Antibody
Full Product Name
AADACL1 Rabbit Polyclonal
Product Gene Name
anti-AADACL1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Arylacetamide deacetylase-like 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-AADACL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AADACL1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Western Blot (WB) of anti-AADACL1 antibody
NCBI/Uniprot data below describe general gene information for AADACL1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH47588.2
[Other Products]
UniProt Secondary Accession #
Q86WZ1; Q9P2I4; B7Z2K4; B7Z3A1; B7Z5U2; B7Z906; B7ZAW6; F5H7K4[Other Products]
UniProt Related Accession #
Q6PIU2[Other Products]
Molecular Weight
31,168 Da
NCBI Official Full Name
AADACL1 protein, partial
NCBI Official Synonym Full Names
neutral cholesterol ester hydrolase 1
NCBI Official Symbol
NCEH1 [Similar Products]
NCBI Official Synonym Symbols
NCEH; AADACL1
[Similar Products]
NCBI Protein Information
neutral cholesterol ester hydrolase 1
UniProt Protein Name
Neutral cholesterol ester hydrolase 1
UniProt Synonym Protein Names
Arylacetamide deacetylase-like 1
UniProt Gene Name
NCEH1 [Similar Products]
UniProt Synonym Gene Names
AADACL1; KIAA1363; NCEH [Similar Products]
UniProt Entry Name
NCEH1_HUMAN
UniProt Comments for AADACL1
AADACL1: a single-pass type II membrane microsomal protein. Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine). Elevated in invasive cancer cells from several different tumor types. May be involved in the elevated neutral ether lipid content and elevated LPA signaling in cancer cells. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. A key enzymatic node regulating an ether lipid signaling network in cancer; regulates MAGE and lysophospholipid levels in invasive cancer cells. Three alternatively spliced human isoforms have been described.
Protein type: Membrane protein, integral; Hydrolase; EC 3.1.1.-
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: sterol esterase activity
Biological Process: lipid catabolic process
Research Articles on AADACL1
1. Together, the results define the kinetics of inhibition of KIAA1363 by active metabolites of agrochemicals and indicate that KIAA1363 is highly sensitive to inhibition by these compounds.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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