Full Product Name
Rabbit Anti-human Apo CII Antibody
Product Synonym Names
Rabbit Anti-human Apo CII
Product Gene Name
anti-Apo CII antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (45449239..45452822). Location: 19q13.2
3D Structure
ModBase 3D Structure for P02655
Specificity
Specifically binds to human apo CII.
Concentration
100ug/100ul (lot specific)
Immunogen
Apo CII recombinant protein.
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-Apo CII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Apo CII antibody
Cholesterol Related Antibodies
Applications Tested/Suitable for anti-Apo CII antibody
ELISA (EIA)
Application Notes for anti-Apo CII antibody
Dilution for immunoblot and ELISA range: 1:1,000 to 1:4,000.
NCBI/Uniprot data below describe general gene information for Apo CII. It may not necessarily be applicable to this product.
NCBI Accession #
AAA98743.1
[Other Products]
UniProt Primary Accession #
P02655
[Other Products]
UniProt Secondary Accession #
Q9BS39; Q9UDE3; Q9UNK3; C0JYY4[Other Products]
UniProt Related Accession #
P02655[Other Products]
Molecular Weight
11,284 Da
NCBI Official Full Name
apolipoprotein CII
NCBI Official Synonym Full Names
apolipoprotein C-II
NCBI Official Symbol
APOC2 [Similar Products]
NCBI Official Synonym Symbols
APO-CII; APOC-II
[Similar Products]
NCBI Protein Information
apolipoprotein C-II; apolipoprotein C2
UniProt Protein Name
Apolipoprotein C-II
UniProt Synonym Protein Names
Apolipoprotein C2
UniProt Gene Name
APOC2 [Similar Products]
UniProt Synonym Gene Names
APC2; Apo-CII; ApoC-II [Similar Products]
UniProt Entry Name
APOC2_HUMAN
NCBI Summary for Apo CII
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
UniProt Comments for Apo CII
Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
Subcellular location: Secreted.
Tissue specificity: Secreted in plasma.
Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23
Sequence similarities: Belongs to the apolipoprotein C2 family.
Research Articles on Apo CII
1. STAT1 bound on multienhancer 2 cooperates with RXRalpha located on apoCII promoter and upregulates apoCII expression only in macrophages.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
