Product Name
ApoC2, Native Protein
Full Product Name
ApoC2 protein
Product Synonym Names
ApoC 2 protein; ApoC2; ApoC 2; ApoC-2 protein; APOC2 protein; Apolipoprotein C2 protein; ApoC-2
Product Gene Name
ApoC2 native protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
> 98% pure
Form/Format
10 mM PBS, 0.15 M NaCl, 0.02 % NaN3, 0.5 mM EDTA, pH 7.2
Biological Significance
Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries[1], which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.
Preparation and Storage
Store at 2-8 degree C for short term storage. For long term storage aliquot and store at -20 degree C
Other Notes
Small volumes of ApoC2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ApoC2 native protein
Purified native Human ApoC2 protein
Product Categories/Family for ApoC2 native protein
Cardiac Markers; Native Protein
NCBI/Uniprot data below describe general gene information for ApoC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000474.2
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NCBI GenBank Nucleotide #
NM_000483.4
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UniProt Secondary Accession #
Q9BS39; Q9UDE3; Q9UNK3; C0JYY4[Other Products]
UniProt Related Accession #
P02655[Other Products]
Molecular Weight
11,284 Da
NCBI Official Full Name
apolipoprotein C-II
NCBI Official Synonym Full Names
apolipoprotein C-II
NCBI Official Symbol
APOC2 [Similar Products]
NCBI Official Synonym Symbols
APO-CII; APOC-II
[Similar Products]
NCBI Protein Information
apolipoprotein C-II
UniProt Protein Name
Apolipoprotein C-II
UniProt Synonym Protein Names
Apolipoprotein C2
Protein Family
Apolipoprotein
UniProt Gene Name
APOC2 [Similar Products]
UniProt Synonym Gene Names
APC2; Apo-CII; ApoC-II; ProapoC-II [Similar Products]
UniProt Entry Name
APOC2_HUMAN
NCBI Summary for ApoC2
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
UniProt Comments for ApoC2
APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular space; chylomicron; early endosome; extracellular region
Molecular Function: phospholipase binding; protein homodimerization activity; lipase inhibitor activity; lipid binding; phospholipase activator activity
Biological Process: positive regulation of fatty acid biosynthetic process; phototransduction, visible light; negative regulation of cholesterol transport; cholesterol efflux; lipoprotein metabolic process; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; negative regulation of catalytic activity; positive regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; retinoid metabolic process; negative regulation of lipid metabolic process; lipid catabolic process
Disease: Apolipoprotein C-ii Deficiency
Research Articles on ApoC2
1. Six apolipoproteins (APOA1, APOA2, APOB, APOC2, APOC3, and APOE) were able to differentiate bladder cancer from hernia. SAA4 was significantly increased in bladder cancer subgroups, whereas ProEGF was significantly decreased in bladder cancer subgroups.
Precautions
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Disclaimer
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