Product Name
Choline Acetyltransferase (CHAT), Antibody
Full Product Name
Choline Acetyltransferase Antibody
Product Gene Name
anti-CHAT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28329
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-CHAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHAT antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CHAT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001136401.1
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NCBI GenBank Nucleotide #
NM_001142929.1
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UniProt Primary Accession #
P28329
[Other Products]
UniProt Secondary Accession #
Q16488; Q9BQ23; Q9BQ35; Q9BQE1; A2BDF4; A2BDF5[Other Products]
UniProt Related Accession #
P28329[Other Products]
Molecular Weight
70,394 Da[Similar Products]
NCBI Official Full Name
choline O-acetyltransferase isoform 1
NCBI Official Synonym Full Names
choline O-acetyltransferase
NCBI Official Symbol
CHAT [Similar Products]
NCBI Official Synonym Symbols
CMS6; CMS1A; CMS1A2; CHOACTASE
[Similar Products]
NCBI Protein Information
choline O-acetyltransferase
UniProt Protein Name
Choline O-acetyltransferase
Protein Family
(Z)-3-hexen-1-ol acetyltransferase
UniProt Gene Name
CHAT [Similar Products]
UniProt Synonym Gene Names
CHOACTase; ChAT; Choline acetylase [Similar Products]
NCBI Summary for CHAT
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
UniProt Comments for CHAT
CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described.
Protein type: Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: choline O-acetyltransferase activity
Biological Process: neurotransmitter secretion; phosphatidylcholine biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
Research Articles on CHAT
1. In conclusion, our meta-analysis indicated CHAT rs2177369 polymorphism might play a protective role in AD, while rs3810950 variant was a risk factor for AD but its single heterozygous mutations might not influence susceptibility to AD.
Precautions
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