CELSR3, Polyclonal Antibody

Anti-CELSR3 Antibody (N-Terminus) IHC-plus; CELSR3; Anchor protein; Cadherin family member 11; CDHF11; EGF-like protein 1; EGF-like-domain; multiple 1; Epidermal growth factor-like 1; Flamingo homolog 1; FMI1; KIAA0812; MEGF2; Megf3; HFMI1; Multiple EGF-like domains 2; RESDA1; EGFL1; Human CELSR3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human CELSR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-CELSR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CELSR3 is an Orphan-U GPCR with an unknown ligand.

Subfamily:-Orphan-U">Family: GPCR
Subfamily: Orphan-U

Immunohistochemistry (IHC - Paraffin)

IHC-P (36 ug/ml)

Anti-CELSR3 antibody IHC of human brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

358,640 Da

cadherin, EGF LAG seven-pass G-type receptor 3

cadherin EGF LAG seven-pass G-type receptor 3; anchor protein; EGF-like protein 1; flamingo homolog 1; cadherin family member 11; EGF-like-domain, multiple 1; multiple EGF-like domains protein 2; epidermal growth factor-like protein 1; multiple epidermal growth factor-like domains protein 2; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Cadherin EGF LAG seven-pass G-type receptor 3

CDHF11; EGFL1; FMI1; KIAA0812; MEGF2; EGF-like protein 1; hFmi1; Multiple EGF-like domains protein 2  [Similar Products]

CELR3_HUMAN

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; protein binding; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; axonal fasciculation; neuron migration; cilium biogenesis; homophilic cell adhesion

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