Full Product Name
GLRB Antibody, HRP conjugated
Product Synonym Names
Glycine receptor subunit beta; Glycine receptor 58 kDa subunit; GLRB
Product Gene Name
anti-GLRB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48167
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Glycine receptor subunit beta protein (355-472AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GLRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GLRB antibody
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Product Categories/Family for anti-GLRB antibody
Neuroscience; Signal transduction
Applications Tested/Suitable for anti-GLRB antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GLRB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000815.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000824.4
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UniProt Primary Accession #
P48167
[Other Products]
UniProt Secondary Accession #
A8K3K2; D3DP23; F5GWE1[Other Products]
UniProt Related Accession #
P48167[Other Products]
Molecular Weight
34,944 Da
NCBI Official Full Name
glycine receptor subunit beta isoform A
NCBI Official Synonym Full Names
glycine receptor beta
NCBI Official Symbol
GLRB [Similar Products]
NCBI Official Synonym Symbols
HKPX2
[Similar Products]
NCBI Protein Information
glycine receptor subunit beta
UniProt Protein Name
Glycine receptor subunit beta
UniProt Synonym Protein Names
Glycine receptor 58 kDa subunit
Protein Family
Glycine receptor
UniProt Gene Name
GLRB [Similar Products]
NCBI Summary for GLRB
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for GLRB
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Research Articles on GLRB
1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture.
Precautions
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