Full Product Name
DFNA5 Rabbit Polyclonal
Product Gene Name
anti-DFNA5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Deafness, autosomal dominant 5
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DFNA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DFNA5 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DFNA5. It may not necessarily be applicable to this product.
NCBI Accession #
AAI25067.1
[Other Products]
UniProt Secondary Accession #
O14590; Q08AQ8; Q9UBV3; A4D156; B2RAX9; B3KT05[Other Products]
UniProt Related Accession #
O60443[Other Products]
Molecular Weight
36,043 Da
NCBI Official Full Name
DFNA5 protein, partial
NCBI Official Synonym Full Names
DFNA5, deafness associated tumor suppressor
NCBI Official Symbol
DFNA5 [Similar Products]
NCBI Official Synonym Symbols
ICERE-1
[Similar Products]
NCBI Protein Information
non-syndromic hearing impairment protein 5
UniProt Protein Name
Non-syndromic hearing impairment protein 5
UniProt Synonym Protein Names
Inversely correlated with estrogen receptor expression 1; ICERE-1
Protein Family
Non-syndromic hearing impairment protein
UniProt Gene Name
DFNA5 [Similar Products]
UniProt Synonym Gene Names
ICERE1; ICERE-1 [Similar Products]
UniProt Entry Name
DFNA5_HUMAN
NCBI Summary for DFNA5
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DFNA5
DFNA5: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Defects in DFNA5 are the cause of deafness autosomal dominant type 5 (DFNA5). DFNA5 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Is a tumor suppressor gene with an important role in major types of tumors. Could be a valuable molecular marker in cancer. Belongs to the gasdermin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 7p15
Cellular Component: cytoplasm
Biological Process: apoptosis; inner ear receptor cell differentiation; negative regulation of cell proliferation; sensory perception of sound
Disease: Deafness, Autosomal Dominant 5
Research Articles on DFNA5
1. Genetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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