Full Product Name
GLRB Antibody
Product Synonym Names
Glycine receptor subunit beta; Glycine receptor 58 kDa subunit
Product Gene Name
anti-GLRB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48167
Species Reactivity
Human, Mouse, Rat
Specificity
GLRB Antibody detects endogenous levels of total GLRB
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-GLRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GLRB antibody
Western Blot (WB)
Application Notes for anti-GLRB antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-GLRB antibody
Western blot analysis of extracts from A549 cells and K562 cells, using GLRB antibody.
NCBI/Uniprot data below describe general gene information for GLRB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000815.1
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NCBI GenBank Nucleotide #
NM_000824.4
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UniProt Primary Accession #
P48167
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UniProt Secondary Accession #
A8K3K2; D3DP23; F5GWE1[Other Products]
UniProt Related Accession #
P48167[Other Products]
NCBI Official Full Name
glycine receptor subunit beta isoform A
NCBI Official Synonym Full Names
glycine receptor beta
NCBI Official Symbol
GLRB [Similar Products]
NCBI Official Synonym Symbols
HKPX2
[Similar Products]
NCBI Protein Information
glycine receptor subunit beta
UniProt Protein Name
Glycine receptor subunit beta
UniProt Synonym Protein Names
Glycine receptor 58 kDa subunit
Protein Family
Glycine receptor
UniProt Gene Name
GLRB [Similar Products]
NCBI Summary for GLRB
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for GLRB
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Research Articles on GLRB
1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture.
Precautions
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