Product Name
GJA3, cDNA Clone
Full Product Name
GJA3 cDNA Clone
Product Gene Name
GJA3 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGGCGACT GGAGCTTTCT GGGAAGACTC TTAGAAAATG CACAGGAGCA CTCCACGGTC ATCGGCAAGG TTTGGCTGAC CGTGCTGTTC ATCTTCCGCA TCTTGGTGCT GGGGGCCGCG GCGGAGGACG TGTGGGGCGA TGAGCAGTCA GACTTCACCT GCAACACCCA GCAGCCGGGC TGCGAGAACG TCTGCTACGA CAGGGCCTTC CCCATCTCCC ACATCCGCTT CTGGGCGCTG CAGATCATCT TCGTGTCCAC GCCCACCCTC ATCTACCTGG GCCACGTGCT GCACATCGTG CGCATGGAAG AGAAGAAGAA AGAGAGGGAG GAGGAGGAGC AGCTGAAGAG AGAGAGCCCC AGCCCCAAGG AGCCACCGCA GGACAATCCC TCGTCGCGGG ACGACCGCGG CAGGGTGCGC ATGGCCGGGG CGCTGCTGCG GACCTACGTC TTCAACATCA TCTTCAAGAC GCTGTTCGAG GTGGGCTTCA TCGCCGGCCA GTACTTTCTG TACGGCTTCG AGCTGAAGCC GCTCTACCGC TGCGACCGCT GGCCCTGCCC CAACACGGTG GACTGCTTCA TCTCCAGGCC CACGGAGAAG ACCATCTTCA TCATCTTCAT GCTGGCGGTG GCCTGCGCGT CCCTGCTGCT CAACATGCTG GAGATCTACC ACCTGGGCTG GAAGAAGCTC AAGCAGGGCG TGACCAGCCG CCTCGGCCCG GACGCCTCCG AGGCCCCGCT GGGGACAGCC GATCCCCCGC CCCTGCCCCC CAGCTCCCGG CCGCCCGCCG TTGCCATCGG GTTCCCACCC TACTATGCGC ACACCGCTGC GCCCCTGGGA CAGGCCCGCG CCGTGGGCTA CCCCGGGGCC CCGCCACCAG CCGCGGACTT CAAAATGCTA GCCCTGACCG AGGCGCGCGG AAAGGGCCAG TCCGCCAAGC TCTACAACGG CCACCACCAC CTGCTGATGA CTGAGCAGAA CTGGGCCAAC CAGGCGGCCG AGCGGCAGCC CCCGGCACTC AAGGCTTACC CGGCAGCGTC CACGCCTGCA GCCCCCAGCC CCGTCGGCAG CAGCTCCCCG CCACTCGCGC ACGAGGCTGA GGCGGGCGCG GCGCCCCTGC TGCTGGATGG GAGCGGCAGC AGTCTGGAGG GGAGCGCCCT GGCAGGGACC CCCGAGGAGG AGGAGCAGGC CGTGACCACC GCGGCCCAGA TGCACCAGCC GCCCTTGCCC CTCGGAGACC CAGGTCGGGC CAGCAAGGCC AGCAGGGCCA GCAGCGGGCG GGCCAGACCG GAGGACTTGG CCATCTAG
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GJA3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GJA3. It may not necessarily be applicable to this product.
NCBI Accession #
BC121137
[Other Products]
UniProt Secondary Accession #
Q0VAB7; Q9H537[Other Products]
UniProt Related Accession #
Q9Y6H8[Other Products]
Molecular Weight
47,410 Da
NCBI Official Full Name
Homo sapiens gap junction protein, alpha 3, 46kDa, mRNA
NCBI Official Synonym Full Names
gap junction protein alpha 3
NCBI Official Symbol
GJA3 [Similar Products]
NCBI Official Synonym Symbols
CX46; CZP3; CTRCT14
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NCBI Protein Information
gap junction alpha-3 protein
UniProt Protein Name
Gap junction alpha-3 protein
UniProt Synonym Protein Names
Connexin-46; Cx46
Protein Family
Gap junction alpha-3 protein
UniProt Gene Name
GJA3 [Similar Products]
UniProt Synonym Gene Names
Cx46 [Similar Products]
UniProt Entry Name
CXA3_HUMAN
NCBI Summary for GJA3
The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
UniProt Comments for GJA3
GJA3: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in GJA3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the connexin family. Alpha-type (group II) subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q12.11
Biological Process: cell-cell signaling; visual perception
Disease: Cataract 14, Multiple Types
Research Articles on GJA3
1. Taken together, in Jar cells, placental connexins 43 and 46 are regulated during periods of low oxygen in opposite manners
Precautions
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Disclaimer
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