Product Name
Corticosteroid 11-beta-dehydrogenase isozyme 2 (Hsd11b2), Recombinant Protein
Full Product Name
Recombinant Mouse Corticosteroid 11-beta-dehydrogenase isozyme 2 (Hsd11b2)
Product Gene Name
Hsd11b2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-386aa, Full length protein
Sequence
MERWPWPSGG AWLLVAARAL LQLLRSDLRL GRPLLAALAL LAALDWLCQR LLPPPAALVV LAGAGWIALS RLARPPRLPV ATRAVLITGC DTGFGKETAK KLDAMGFTVL ATVLDLNSPG ALELRDLCSP RLKLLQMDLT KAEDISRVLE ITKAHTASTG LWGLVNNAGL NIVVADVELS PVATFRKCME VNFFGALELT KGLLPLLRHS RGRIVTVGSP AGDMPYPCLA AYGTSKAAIA LLMDTFGCEL LPWGIKVSII KPGCFKTDAV TNVNLWEKRK QLLLANIPRE LLQAYGEDYI EHVHGQFLNS LRMALPDLSP VVDAIIDALL AAQPRSRYYP GRGLGLMYFI HHYLPEGLRR CFLQNFFINH LLPRALRPGQ HGPAPA
3D Structure
ModBase 3D Structure for P51661
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hsd11b2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Hsd11b2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032315.2
[Other Products]
NCBI GenBank Nucleotide #
NM_008289.2
[Other Products]
UniProt Primary Accession #
P51661
[Other Products]
UniProt Secondary Accession #
Q91WK3[Other Products]
UniProt Related Accession #
P51661[Other Products]
Molecular Weight
42,187 Da
NCBI Official Full Name
corticosteroid 11-beta-dehydrogenase isozyme 2
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 2
NCBI Official Symbol
Hsd11b2 [Similar Products]
NCBI Official Synonym Symbols
11HSD2
[Similar Products]
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Protein Family
Corticosteroid 11-beta-dehydrogenase isozyme
UniProt Gene Name
Hsd11b2 [Similar Products]
UniProt Synonym Gene Names
Hsd11k; 11-DH2; 11-beta-HSD2 [Similar Products]
UniProt Comments for Hsd11b2
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Research Articles on Hsd11b2
1. Kidney-specific deficiency of 11beta-HSD2 leads to Salt-dependent Hypertension, which is attributed to mineralocorticoid receptor-epithelial sodium channel-Na(+)-Cl(-) cotransporter activation in the kidney.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
