Thyroid Hormone Receptor beta, Antibody

C-ERBA-BETA; ERBA2; NR1A2; THR1

For Research Use Only. Not for use in diagnostic procedures.

Thyroid Hormone Receptor beta antibody detects endogenous levels of total Thyroid Hormone Receptor beta protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year

Small volumes of anti-THB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Thyroid Hormone Receptor beta antibody.

Western blot analysis of extracts from LOVO cells, using Thyroid Hormone Receptor beta antibody.

54,449 Da

thyroid hormone receptor beta

thyroid hormone receptor beta

Thyroid hormone receptor beta

ERBA2; NR1A2; THR1  [Similar Products]

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sharon Y. Wu, J. Clin. Endocrinol. Metab., May 2006; 91: 1887-1895. J. D. Safer, J. Clin. Endocrinol. Metab., Sep 1999; 84: 3099-3109. Joaquin Lado-Abeal, J. Clin. Endocrinol. Metab., Mar 2005; 90: 1760-1767. Sunee Mamanasiri, J. Clin. Endocrinol. Metab., Sep 2006; 91: 3471-3477.

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