Full Product Name
Anti-Human CD33 Monoclonal Antibody (PE/Cy5 Conjugated)
Product Synonym Names
Myeloid cell surface antigen CD33; CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; SIGLEC3
Product Gene Name
anti-CD33 antibody
[Similar Products]
Matching Pairs
Antibody: CD33 Clone #6C5 (MBS2556889)
Isotype Control: IgG1, kappa Clone #MOPC-21 (MBS2557735)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20138
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Preparation and Storage
Store at 2-8 degree C and protected from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD33 antibody
CD33 is a 67 kD type I transmembrane glycoprotein also known as Siglec-3, gp67, and p67. It is a sialoadhesion immunoglobulin superfamily member expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes and hematopoietic stem cells. CD33 functions as a sialic acid-dependent cell adhesion molecule with carbohydrate/lectin binding activity.
Applications Tested/Suitable for anti-CD33 antibody
Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD33. It may not necessarily be applicable to this product.
NCBI Accession #
P20138.2
[Other Products]
UniProt Primary Accession #
P20138
[Other Products]
UniProt Related Accession #
P20138[Other Products]
NCBI Official Full Name
Myeloid cell surface antigen CD33
NCBI Official Synonym Full Names
CD33 molecule
NCBI Official Symbol
CD33 [Similar Products]
NCBI Official Synonym Symbols
p67; SIGLEC3; SIGLEC-3
[Similar Products]
NCBI Protein Information
myeloid cell surface antigen CD33
UniProt Protein Name
Myeloid cell surface antigen CD33
UniProt Synonym Protein Names
Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33
Protein Family
Myeloid cell surface antigen
UniProt Gene Name
CD33 [Similar Products]
UniProt Synonym Gene Names
SIGLEC3; Siglec-3 [Similar Products]
UniProt Entry Name
CD33_HUMAN
UniProt Comments for CD33
CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; receptor activity; carbohydrate binding
Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion
Product References and Citations for anti-CD33 antibody
1. Favaloro E, et al. 1988. Br. J. Haematol. 69:163. 2. Freeman S, et al. 1995. Blood 85:2005.
Research Articles on CD33
1. These findings demonstrate that C1q and it's globular region interact with CD33 to activate its inhibitory motifs, while the collagen-like region does not. Whole C1q is required to crosslink CD33 and LAIR-1 and concurrently activate CD33/LAIR-1 inhibitory motifs.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
