11-cis retinol dehydrogenase, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of RDH5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2606709 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 11-cis retinol dehydrogenase (RDH5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RDH5. The ELISA analytical biochemical technique of the MBS2606709 kit is based on RDH5 antibody-RDH5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RDH5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RDH5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

34,979 Da

retinol dehydrogenase 5

11-cis retinol dehydrogenase

11-cis retinol dehydrogenase

HSD17B9; RDH1; SDR9C5; 11-cis RDH; 11-cis RoDH; 9cRDH  [Similar Products]

RDH1_HUMAN

This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]

RDH5: Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. Defects in RDH5 are a cause of retinitis punctata albescens (RPA); also known as fundus albipunctatus (FA). RPA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Endoplasmic reticulum; Oxidoreductase; EC 1.1.1.315; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane

Molecular Function: retinol dehydrogenase activity

Biological Process: phototransduction, visible light; retinoid metabolic process; retinol metabolic process; visual perception

Disease: Fundus Albipunctatus

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