Product Name
Melanophilin (Mlph), Blocking Peptide
Full Product Name
Melanophilin Immunizing Peptide
Product Synonym Names
2210418F23Rik; melanophilin; Mlph; ln; l1Rk3; Slac-2a; D1Wsu84e; l(1)-3Rk; 5031433I09Rik; leaden; AW228792; OTTMUSP00000025451; Melanophilin; Melanophilin (mouse)
Product Gene Name
Mlph blocking peptide
[Similar Products]
Melanophilin peptide (MBS425662) is used for blocking the activity of Melanophilin antibody (MBS421445)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-ARHIFAKP VMAQQP
Species Reactivity
Mouse, Rat
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Mlph blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Mlph. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443748.2
[Other Products]
NCBI GenBank Nucleotide #
NM_053015.3
[Other Products]
UniProt Secondary Accession #
Q3UFV7; Q99N53[Other Products]
UniProt Related Accession #
Q91V27[Other Products]
Molecular Weight
65,052 Da
NCBI Official Full Name
melanophilin
NCBI Official Synonym Full Names
melanophilin
NCBI Official Symbol
Mlph [Similar Products]
NCBI Official Synonym Symbols
ln; l1Rk3; Slac-2a; AW228792; D1Wsu84e; l(1)-3Rk; 2210418F23Rik; 5031433I09Rik
[Similar Products]
NCBI Protein Information
melanophilin
UniProt Protein Name
Melanophilin
UniProt Synonym Protein Names
Exophilin-3; Leaden protein; Slp homolog lacking C2 domains a; SlaC2-a; Synaptotagmin-like protein 2a
Protein Family
Melanophilin
UniProt Gene Name
Mlph [Similar Products]
UniProt Synonym Gene Names
Ln; Slac2a; SlaC2-a [Similar Products]
UniProt Entry Name
MELPH_MOUSE
UniProt Comments for Mlph
MLPH: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: actin cytoskeleton; cortical actin cytoskeleton; dendrite; melanosome; microtubule organizing center; perinuclear region of cytoplasm; stress fiber
Molecular Function: actin binding; metal ion binding; microtubule plus-end binding; myosin binding; myosin V binding; protein binding; Rab GTPase binding
Biological Process: intracellular protein transport; melanocyte differentiation; melanosome localization; pigmentation; protein targeting
Research Articles on Mlph
1. The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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