Product Name
Amiloride-sensitive sodium channel subunit alpha (SCNN1A), Recombinant Protein
Full Product Name
Recombinant Bovine Amiloride-sensitive sodium channel subunit alpha (SCNN1A), partial
Product Gene Name
SCNN1A recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
91-524
Sequence
SYPVSLNINL NSDKLVFPAV SICTLNPYRY KEIQEELEEL DRITEQTLFD LYKYNSSKTL VAHARSRRDL REPLPHPLQR LPVPAPPHAA RGVRRAGSSM RDNNPQVNRK DWKIGFQLCN QNKSDCFYQT YSSGVDAVRE WYRFHYINIL SRRRQDTSPS LEEDVLGKFI FTCRFNQDSC NEANYSHFHH PMYGNCYTFN DKNSSNLWMS SMPGVNNGLS LTLRTEQNDF IPLLSTVTGA RVMVHERDEP AFMDDAGFNL RPGVETSISM SKEAVDRLGG DYGDCTKNGS EVPVENLYNT KYTQQVCIHS CFQESMIKEC GCAYIFYPRP DGVEFCDYRK HNSWGYCYYK LQDAFSSDRL GCFTKCRKPC SVTIYKLSAS YSQWPSATSQ DWVFQMLSRQ NNYTIKNKRD GVAKLNIFFK ELNYKSNSES PSVT
3D Structure
ModBase 3D Structure for P55270
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Bos taurus (Bovine)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SCNN1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SCNN1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_777023.1
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NCBI GenBank Nucleotide #
NM_174598.3
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UniProt Primary Accession #
P55270
[Other Products]
UniProt Secondary Accession #
O02851[Other Products]
UniProt Related Accession #
P55270[Other Products]
Molecular Weight
73,793 Da
NCBI Official Full Name
amiloride-sensitive sodium channel subunit alpha
NCBI Official Synonym Full Names
sodium channel epithelial 1 alpha subunit
NCBI Official Symbol
SCNN1A [Similar Products]
NCBI Protein Information
amiloride-sensitive sodium channel subunit alpha
UniProt Protein Name
Amiloride-sensitive sodium channel subunit alpha
UniProt Synonym Protein Names
Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA
Protein Family
Amiloride-sensitive sodium channel
UniProt Gene Name
SCNN1A [Similar Products]
UniProt Synonym Gene Names
Alpha-ENaC [Similar Products]
UniProt Comments for SCNN1A
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
