Product Synonym Names
ALAS2; 5-aminolevulinic acid synthase 2; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2
Product Gene Name
anti-ALAS2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22557
Species Reactivity
Human, Mouse, Rat
Purity/Purification
ProA affinity purified
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-ALAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALAS2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin
NCBI/Uniprot data below describe general gene information for ALAS2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000023.2
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NCBI GenBank Nucleotide #
NM_000032.5
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UniProt Primary Accession #
P22557
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UniProt Secondary Accession #
Q13735; Q5JZF5; Q8N6H3; A8K3F0; A8K6C4[Other Products]
UniProt Related Accession #
P22557[Other Products]
Molecular Weight
63,487 Da
NCBI Official Full Name
5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform a
NCBI Official Synonym Full Names
5'-aminolevulinate synthase 2
NCBI Official Symbol
ALAS2 [Similar Products]
NCBI Official Synonym Symbols
ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E; SIDBA1
[Similar Products]
NCBI Protein Information
5-aminolevulinate synthase, erythroid-specific, mitochondrial
UniProt Protein Name
5-aminolevulinate synthase, erythroid-specific, mitochondrial
UniProt Synonym Protein Names
5-aminolevulinic acid synthase 2; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2
Protein Family
Alanine--tRNA ligase
UniProt Gene Name
ALAS2 [Similar Products]
UniProt Synonym Gene Names
ALASE; ASB; ALAS-E [Similar Products]
NCBI Summary for ALAS2
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ALAS2
MiscellaneousThere are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.
Research Articles on ALAS2
1. A novel ALAS2 missense mutation in exon 9 affects the enzymatic activity of ALAS2 by affecting its interaction with the cofactor pyridoxal 5'-phosphate in X-linked sideroblastic anemia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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