Lacritin, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against LACRT. It has beenselected for its ability to recognize LACRT in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-LACRT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Mouse Heart Tissue.

Western Blot: Sample: Recombinant protein.

DAB staining on fromalin fixed paraffin-embedded Liver tissue)

14,246 Da

lacritin

extracellular glycoprotein lacritin

Extracellular glycoprotein lacritin

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

LACRT: Modulates secretion by lacrimal acinar cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular region; extracellular space; secretory granule

Molecular Function: collagen binding; fibronectin binding; growth factor activity; laminin-1 binding; protein N-terminus binding

Biological Process: calcineurin-NFAT signaling pathway; calcium-mediated signaling; defense response to bacterium; negative regulation of apoptosis; negative regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of macroautophagy; positive regulation of NFAT protein import into nucleus; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of secretion; protein amino acid acetylation; protein localization to Golgi apparatus

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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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