CD71, Monoclonal Antibody

Transferrin receptor protein 1; Tfrc; TR; TfR; TfR1; Trfr; CD71

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

R17 217.1.3/TIB-219

Rat

Liquid; PBS with 0.05% Proclin300, 1% BSA

Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CD71 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD71 is a 95 kD type II heterodimeric transmembrane glycoprotein that is also known as T9 and transferrin receptor. CD71 is expressed on proliferating cells, reticulocytes, and erythroid precursors. Its expression is very low on resting leukocytes. CD71 plays a role in the control of cellular proliferation by facilitating the uptake of iron via ferrotransferrin binding and the recycling of apotransferrin to the cell surface.

Flow Cytometry (FC/FACS)

C57BL/6 murine splenocytes are stained with Anti-Mouse CD71 Monoclonal Antibody (Alexa Fluor 488 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.

85,731 Da

transferrin receptor

transferrin receptor protein 1

Transferrin receptor protein 1

Trfr; TR; TfR; TfR1; Trfr  [Similar Products]

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).

1. Hentze MW, et al. 1996. P. Natl. Acad. Sci. USA 93:8175. 2. Trowbridge IS, et al. 1993. Annu. Rev. Cell Biol. 9:129. 3. Trowbridge I, et al. 1982. J. Cell Physiol. 112:403. 4. Kuhn LC, et al. 1984. Cell 37:95.

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