GluA1/GluR1 Glutamate Receptor, Monoclonal Antibody

AMPA 1; AMPA selective glutamate receptor 1; Glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluRK1; Glr-1; Glur-1; HIPA; Glur1; GluR-A; AI853806; 2900051M01Rik; GluRA; Glr1; MGC13325; GLUH1; GluA1; GLUR1; HBGR1; GLURA; gluR-; GluA1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

S355-1

Mouse

Protein G Purified

1mg/mL (lot specific)

-20 degree C

Small volumes of anti-Gria1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background Info: Detects ~100kDa. Does not cross-react with GluR2.

Scientific Background: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).

Cell Signaling, Neuroscience

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

1:1000 WB

101,555 Da[Similar Products]

glutamate receptor, ionotropic, AMPA 1

glutamate receptor 1; GluR1; gluR-1; gluR-K1; glutamate receptor A; glutamate receptor subunit GluR1; AMPA-selective glutamate receptor 1; glutamate receptor, ionotropic, AMPA1 (alpha 1)

Glutamate receptor 1

Glur1; GluR-1; GluA1  [Similar Products]

GRIA1_RAT

mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning [RGD, Feb 2006]

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium

Cellular Component: endoplasmic reticulum membrane; neuron projection; cell surface; protein complex; endoplasmic reticulum; dendrite; early endosome; postsynaptic density; dendritic spine; integral to membrane; excitatory synapse; cytosol; asymmetric synapse; postsynaptic membrane; synaptic vesicle; recycling endosome; membrane; cell soma; plasma membrane; ionotropic glutamate receptor complex; synapse; dendritic shaft; neuromuscular junction; cell junction

Molecular Function: protein domain specific binding; identical protein binding; protein homodimerization activity; myosin V binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; protein kinase binding; PDZ domain binding; small GTPase binding; protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; protein kinase A binding; beta-2 adrenergic receptor binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; adenylate cyclase binding

Biological Process: response to drug; regulation of synaptic transmission; synaptic transmission, glutamatergic; response to peptide hormone stimulus; response to toxin; response to lithium ion; response to arsenic; generation of action potential; regulation of synaptic plasticity; response to cocaine; response to organic cyclic substance; positive regulation of synaptic transmission; response to estradiol stimulus; synaptic transmission; long-term memory; spinal cord development; ionotropic glutamate receptor signaling pathway; receptor internalization; regulation of receptor recycling; response to electrical stimulus; positive regulation of membrane potential

1. Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218. 2. Puckett, C., et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561. 3. Gregor, P., et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.