Product Name
SPATA7, Polyclonal Antibody
Full Product Name
SPATA7 Antibody
Product Synonym Names
HSD3; LCA3; HSD-3.1; HEL-S-296
Product Gene Name
anti-SPATA7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9P0W8
Specificity
The antibody detects endogenous levels of total SPATA7 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.5 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human spermatogenesis associated 7
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-SPATA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPATA7 antibody
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-SPATA7 antibody
Total protein Ab
Applications Tested/Suitable for anti-SPATA7 antibody
Immunohistochemistry (IHC)
Application Notes for anti-SPATA7 antibody
Immunohistochemistry: 1:50-1:200
Immunohistochemistry (IHC) of anti-SPATA7 antibody
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
Immunohistochemistry (IHC) of anti-SPATA7 antibody
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/30.
NCBI/Uniprot data below describe general gene information for SPATA7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035518.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001040428.3
[Other Products]
UniProt Primary Accession #
Q9P0W8
[Other Products]
UniProt Secondary Accession #
Q5BKY5; Q8WX30; Q96HF3; Q9H0X0; Q9P0W7[Other Products]
UniProt Related Accession #
Q9P0W8[Other Products]
Molecular Weight
51,931 Da
NCBI Official Full Name
spermatogenesis-associated protein 7 isoform 2
NCBI Official Synonym Full Names
spermatogenesis associated 7
NCBI Official Symbol
SPATA7 [Similar Products]
NCBI Official Synonym Symbols
HSD3; LCA3; HSD-3.1; HEL-S-296
[Similar Products]
NCBI Protein Information
spermatogenesis-associated protein 7
UniProt Protein Name
Spermatogenesis-associated protein 7
UniProt Synonym Protein Names
HSD-3.1; Spermatogenesis-associated protein HSD3
Protein Family
Spermatogenesis-associated protein
UniProt Gene Name
SPATA7 [Similar Products]
UniProt Synonym Gene Names
HSD3 [Similar Products]
UniProt Entry Name
SPAT7_HUMAN
NCBI Summary for SPATA7
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
UniProt Comments for SPATA7
SPATA7: May be involved in retinal function. Defects in SPATA7 are the cause of Leber congenital amaurosis type 3 (LCA3). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in SPATA7 are a cause of retinitis pigmentosa autosomal recessive (ARRP). ARRP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q31.3
Cellular Component: microtubule cytoskeleton; axoneme; photoreceptor connecting cilium
Molecular Function: protein binding
Biological Process: visual perception; photoreceptor cell maintenance; response to stimulus
Disease: Leber Congenital Amaurosis 3
Research Articles on SPATA7
1. A novel homozygous large deletion in SPATA7 associated with juvenile retinitis pigmentosa has been found in a consanguineous Israeli Muslim Arab family.
Precautions
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Disclaimer
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