Dopamine D5 Receptor, Polyclonal Antibody

D(1B) dopamine receptor; D1B dopamine receptor; DBDR; DRD 1B; DRD 5; DRD1L2 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

FITC-Conjugated

0.5-1.5 ug/ul in antibody stabilization buffer (lot specific)

-20 degree C for long term storage

Small volumes of anti-DRD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FITC-Conjugated Dopamine D5 Receptor Antibody
Dopamine receptor mediated by G proteins which inhibit adenylyl cyclase.  Modulates circadian rhtym of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.

ELISA (EIA), Western Blot (WB)

Dot Blot: 1:50,000
ELISA: 1:50,000
Western Blot: 1:1,000-1:1,5000

52,951 Da[Similar Products]

dopamine receptor D5

D(1B) dopamine receptor

D(1B) dopamine receptor

DRD1B; DRD1L2  [Similar Products]

DRD5_HUMAN

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity

Biological Process: adenylate cyclase activation; associative learning; cellular calcium ion homeostasis; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; G-protein signaling, adenylate cyclase activating pathway; learning; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of adenylate cyclase activity; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission; synaptic transmission, dopaminergic; transmission of nerve impulse; wound healing

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential

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