Product Name
MEN1, cDNA Clone
Full Product Name
MEN1 cDNA Clone
Product Gene Name
MEN1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggctga aggccgccca gaagacgctg ttcccgctgc gctccatcga cgacgtggtg cgcctgtttg ctgccgagct gggccgagag gagccggacc tggtgctcct ttccttggtg ctgggcttcg tggagcattt tctggctgtc aaccgcgtca tccctaccaa cgttcccgag ctcaccttcc agcccagccc cgcccccgac ccgcctggcg gcctcaccta ctttcccgtg gccgacctgt ctatcatcgc cgccctctat gcccgcttca ccgcccagat ccgaggcgcc gtcgacctgt ccctctatcc tcgagaaggg ggtgtctcca gccgtgagct ggtgaagaag gtctccgatg tcatatggaa cagcctcagc cgctcctact tcaaggatcg ggcccacatc cagtccctct tcagcttcat cacaggcacc aaattggaca gctccggtgt ggcctttgct gtggttgggg cctgccaggc cctgggtctc cgggatgtcc acctcgccct gtctgaggat catgcctgga gctggctgta cctgaaagga tcatacatgc gctgtgaccg caagatggag gtggcgttca tggtgtgtgc catcaaccct tccattgacc tgcacaccga ctcgctggag cttctgcagc tgcagcagaa gctgctctgg ctgctctatg acctgggaca tctggaaagg taccccatgg ccttagggaa cctggcagat ctagaggagc tggagcccac ccctggccgg ccagacccac tcaccctcta ccacaagggc attgcctcag ccaagaccta ctatcgggat gaacacatct acccctacat gtacctggct ggctaccact gtcgcaaccg caatgtgcgg gaagccctgc aggcctgggc ggacacggcc actgtcatcc aggactacaa ctactgccgg gaagacgagg agatctacaa ggagttcttt gaagtagcca atgatgtcat ccccaacctg ctgaaggagg cagccagctt gctggaggcg ggcgaggagc ggccggggga gcaaagccag ggcacccaga gccaaggttc cgccctccag gaccctgagt gcttcgccca cctgctgcga ttctacgatg gcatctgcaa atgggaggag ggcagtccca cgcctgtgct gcacgtgggc tgggccacct ttcttgtgca gtccctaggc cgttttgagg gacaggtgcg gcagaaggtg cgcatagtga gccgagaggc cgaggcggcc gaggccgagg agccgtgggg cgaggaagcc cgggaaggcc ggcggcgggg cccacggcgg gagtccaagc cagaggagcc cccgccgccc aagaagccag cactggacaa gggcctgggc accggccagg gtgcagtgtc aggacccccc cggaagcctc ctgggactgt cgctggcaca gcccgaggcc ctgaaggtgg cagcacggct caggtgccag cacccgcagc atcaccaccg ccggagggtc cagtgctcac tttccagagt gagaagatga agggcatgaa ggagctgctg gtggccacca agatcaactc gagcgccatc aagctgcaac tcacggcaca gtcgcaagtg cagatgaaga agcagaaagt gtccacccct agtgactaca ctctgtcttt cctcaagcgg cagcgcaaag gcctctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MEN1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MEN1. It may not necessarily be applicable to this product.
NCBI Accession #
BC002544
[Other Products]
UniProt Secondary Accession #
O00632; Q9BUF0; Q9BUK2; A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2[Other Products]
UniProt Related Accession #
O00255[Other Products]
Molecular Weight
63,748 Da
NCBI Official Full Name
Homo sapiens multiple endocrine neoplasia I, mRNA
NCBI Official Synonym Full Names
menin 1
NCBI Official Symbol
MEN1 [Similar Products]
NCBI Official Synonym Symbols
MEAI; SCG2
[Similar Products]
NCBI Protein Information
menin
UniProt Protein Name
Menin
UniProt Gene Name
MEN1 [Similar Products]
UniProt Synonym Gene Names
SCG2 [Similar Products]
UniProt Entry Name
MEN1_HUMAN
NCBI Summary for MEN1
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
UniProt Comments for MEN1
MEN1: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: chromatin; cleavage furrow; cytoplasm; cytosol; histone methyltransferase complex; nuclear chromatin; nuclear chromosome, telomeric region; nuclear matrix; nucleoplasm; nucleus; protein complex
Molecular Function: chromatin binding; double-stranded DNA binding; four-way junction DNA binding; histone-lysine N-methyltransferase activity; protein binding; protein binding, bridging; protein N-terminus binding; Y-form DNA binding
Biological Process: MAPKKK cascade; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of JNK cascade; negative regulation of osteoblast differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of telomerase activity; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; osteoblast development; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; response to DNA damage stimulus; response to gamma radiation; response to UV
Disease: Multiple Endocrine Neoplasia, Type I
Research Articles on MEN1
1. T) and a germline mutation of exon 11 of RET proto-oncogene (K666M) in a large Italian family and describes clinical manifestations in the carriers.">Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (K666M) in a large Italian family and describes clinical manifestations in the carriers.
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