Dopamine Receptor, D5, Polyclonal Antibody

Anti -Dopamine Receptor, D5

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000004.11 (9783258..9785633). Location: 4p16.1

Polyclonal

Rabbit

Recognizes D5 Dopamine Receptor (Ac-23-35) and the reactivity of D5 Dopamine Receptor is 80%. Does not react to D1 Dopamine Receptor (9-21), D1 Dopamine Receptor, D2 Dopamine Receptor (272-282), D2 Dopamine Receptor, D3 Dopamine Receptor (2-10), D3 Dopamine Receptor, D4 Dopamine Receptor (176-185) and D4 Dopamine Receptor. Highly specific for this peptide sequence and is suitable for immunocytochemical and Western Blot detection of the D5 dopamine receptor.

Serum
Serum

Supplied as a lyophilized powder. Reconstitution with 0.1ml of PBS which contains 10mg/ml BSA.

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-DRD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Receptors

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)

Suitable for use in ELISA, Western Blot and Immunocytochemistry.
Dilution: Western Blot: 1:10-1:50
Immunocytochemistry: 1:10-1:50

52,951 Da[Similar Products]

dopamine receptor D5

D(1B) dopamine receptor; D(1B) dopamine receptor; OTTHUMP00000158603; dopamine D5 receptor; dopamine receptor D1B; d(5) dopamine receptor; D1beta dopamine receptor

D(1B) dopamine receptor

DRD1B; DRD1L2  [Similar Products]

DRD5_HUMAN

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq]

DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; plasma membrane

Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; wound healing; adenylate cyclase activation; response to amphetamine; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; dopamine receptor, phospholipase C activating pathway; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential

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