Full Product Name
EGR2 Antibody, HRP conjugated
Product Synonym Names
E3 SUMO-protein ligase EGR2; AT591; Early growth response protein 2; EGR-2; Zinc finger protein Krox-20; EGR2; KROX20
Product Gene Name
anti-EGR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11161
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human E3 SUMO-protein ligase EGR2 protein (42-245AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-EGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EGR2 antibody
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
Applications Tested/Suitable for anti-EGR2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for EGR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000390.2
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NCBI GenBank Nucleotide #
NM_000399.4
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UniProt Primary Accession #
P11161
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UniProt Secondary Accession #
Q68CZ5; Q8IV26; Q9UNA6; B2R724; B3KRD7[Other Products]
UniProt Related Accession #
P11161[Other Products]
Molecular Weight
44,970 Da
NCBI Official Full Name
E3 SUMO-protein ligase EGR2 isoform a
NCBI Official Synonym Full Names
early growth response 2
NCBI Official Symbol
EGR2 [Similar Products]
NCBI Official Synonym Symbols
AT591; CMT1D; CMT4E; KROX20
[Similar Products]
NCBI Protein Information
E3 SUMO-protein ligase EGR2
UniProt Protein Name
E3 SUMO-protein ligase EGR2
UniProt Synonym Protein Names
AT591; Early growth response protein 2; EGR-2; Zinc finger protein Krox-20
Protein Family
E3 SUMO-protein ligase
UniProt Gene Name
EGR2 [Similar Products]
UniProt Synonym Gene Names
KROX20; EGR-2 [Similar Products]
NCBI Summary for EGR2
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for EGR2
EGR2: sequence-specific DNA-binding transcription factor. Controls systemic autoimmunity; essential for the induction of T-cell anergy. Egr2 and Egr3 induce the suppressive activity of CD4+ T cells, cooperatively inhibiting humoral immune responses by promoting TGF-¿3 secretion. Belongs to the EGR C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: cytoplasm; nucleus
Molecular Function: chromatin binding; protein binding; transcription factor activity; ubiquitin protein ligase binding
Biological Process: brain development; fat cell differentiation; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein export from nucleus; transcription from RNA polymerase II promoter
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1d; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Research Articles on EGR2
1. EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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