Product Name
HIST3H3, Polyclonal Antibody
Full Product Name
HIST3H3 Antibody, FITC conjugated
Product Synonym Names
Histone H3.1tH3/tH3t; H3/g; HIST3H3; H3FT
Product Gene Name
anti-HIST3H3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16695
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Histone H3.1t protein
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HIST3H3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HIST3H3 antibody
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Applications Tested/Suitable for anti-HIST3H3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for HIST3H3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003484.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003493.2
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UniProt Primary Accession #
Q16695
[Other Products]
UniProt Secondary Accession #
Q6FGU4; B2R5K3[Other Products]
UniProt Related Accession #
Q16695[Other Products]
Molecular Weight
15,508 Da
NCBI Official Full Name
histone H3.1t
NCBI Official Synonym Full Names
histone cluster 3 H3
NCBI Official Symbol
HIST3H3 [Similar Products]
NCBI Official Synonym Symbols
H3t; H3.4; H3/g; H3FT
[Similar Products]
NCBI Protein Information
histone H3.1t
UniProt Protein Name
Histone H3.1t
UniProt Synonym Protein Names
H3/g
UniProt Gene Name
HIST3H3 [Similar Products]
UniProt Synonym Gene Names
H3FT; H3/t; H3t [Similar Products]
UniProt Entry Name
H31T_HUMAN
NCBI Summary for HIST3H3
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST3H3
HIST3H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Expressed in testicular cells. Belongs to the histone H3 family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1q42
Cellular Component: nucleoplasm; nucleosome; nucleus
Molecular Function: histone binding; protein binding
Biological Process: double-strand break repair via nonhomologous end joining; negative regulation of protein oligomerization; nucleosome assembly; protein heterotetramerization; telomere capping
Research Articles on HIST3H3
1. Data suggest chromatin exhibits histone 3 methylation markers (H3K4me3, H3K27me3) in fetal brain, heart, and liver, probably to keep progenitor cells in these organs ready for immediate differentiation. (study of 12-week aborted embryo tissues, China)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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