Product Name
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3), Recombinant Protein
Full Product Name
Recombinant Human Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3)
Product Synonym Names
Probable E3 ubiquitin-protein ligase makorin-3; EC=6.3.2.-; RING finger protein 63; Zinc finger protein 127
Product Gene Name
MKRN3 recombinant protein
[Similar Products]
Product Synonym Gene Name
MKRN3; D15S9; RNF63; ZNF127[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-507aa; Full Length
Sequence
MEEPAAPSEA HEAAGAQAGA EAAREGVSGP DLPVCEPSGE SAAPDSALPH AARGWAPFPV APVPAHLRRG GLRPAPASGG GAWPSPLPSR SSGIWTKQII CRYYIHGQCK EGENCRYSHD LSGRKMATEG GVSPPGASAG GGPSTAAHIE PPTQEVAEAP PAASSLSLPV IGSAAERGFF EAERDNADRG AAGGAGVESW ADAIEFVPGQ PYRGRWVASA PEAPLQSSET ERKQMAVGSG LRFCYYASRG VCFRGESCMY LHGDICDMCG LQTLHPMDAA QREEHMRACI EAHEKDMELS FAVQRGMDKV CGICMEVVYE KANPNDRRFG ILSNCNHSFC IRCIRRWRSA RQFENRIVKS CPQCRVTSEL VIPSEFWVEE EEEKQKLIQQ YKEAMSNKAC RYFAEGRGNC PFGDTCFYKH EYPEGWGDEP PGPGGGSFSA YWHQLVEPVR MGEGNMLYKS IKKELVVLRL ASLLFKRFLS LRDELPFSED QWDLLHYELE EYFNLIL
3D Structure
ModBase 3D Structure for Q13064
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MKRN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MKRN3 recombinant protein
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
SDS-PAGE of MKRN3 recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for MKRN3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005655.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005664.3
[Other Products]
UniProt Primary Accession #
Q13064
[Other Products]
UniProt Related Accession #
Q13064[Other Products]
Molecular Weight
55,645 Da
NCBI Official Full Name
probable E3 ubiquitin-protein ligase makorin-3
NCBI Official Synonym Full Names
makorin ring finger protein 3
NCBI Official Symbol
MKRN3 [Similar Products]
NCBI Official Synonym Symbols
CPPB2; D15S9; RNF63; ZFP127; ZNF127
[Similar Products]
NCBI Protein Information
probable E3 ubiquitin-protein ligase makorin-3; RING finger protein 63; zinc finger protein 127
UniProt Protein Name
Probable E3 ubiquitin-protein ligase makorin-3
UniProt Synonym Protein Names
RING finger protein 63; Zinc finger protein 127
Protein Family
Probable E3 ubiquitin-protein ligase makorin
UniProt Gene Name
MKRN3 [Similar Products]
UniProt Synonym Gene Names
D15S9; RNF63; ZNF127 [Similar Products]
UniProt Entry Name
MKRN3_HUMAN
NCBI Summary for MKRN3
The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MKRN3
MKRN3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Protein type: Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 15q11-q13
Cellular Component: ribonucleoprotein complex
Molecular Function: protein binding; zinc ion binding; ligase activity
Biological Process: protein ubiquitination
Disease: Prader-willi Syndrome; Precocious Puberty, Central, 2
Research Articles on MKRN3
1. this study identified novel inherited MKRN3 defects in children with apparently sporadic central precocious puberty, supporting a fundamental role of this peptide in the suppression of the reproductive axis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
