Full Product Name
Eos Polyclonal Antibody
Product Gene Name
anti-Eos antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H2S9
Other Notes
Small volumes of anti-Eos antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Eos. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071910.3
[Other Products]
NCBI GenBank Nucleotide #
NM_022465.3
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UniProt Primary Accession #
Q9H2S9
[Other Products]
UniProt Secondary Accession #
Q96JP3[Other Products]
UniProt Related Accession #
Q9H2S9[Other Products]
Molecular Weight
59,671 Da
NCBI Official Full Name
zinc finger protein Eos isoform a
NCBI Official Synonym Full Names
IKAROS family zinc finger 4
NCBI Official Symbol
IKZF4 [Similar Products]
NCBI Official Synonym Symbols
EOS; ZNFN1A4
[Similar Products]
NCBI Protein Information
zinc finger protein Eos
UniProt Protein Name
Zinc finger protein Eos
UniProt Synonym Protein Names
Ikaros family zinc finger protein 4
Protein Family
Eosinophil peroxidase
UniProt Gene Name
IKZF4 [Similar Products]
UniProt Synonym Gene Names
KIAA1782; ZNFN1A4 [Similar Products]
NCBI Summary for Eos
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
UniProt Comments for Eos
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 ().
Research Articles on Eos
1. IKZF4 polymorphism (rs1701704) was strongly associated with insulin autobody positivity at the time of type 1 diabetes diagnosis
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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