integrin, beta 4, Polyclonal Antibody

integrin; beta 4; ITGB4; CD104

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-ITGB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

106,779 Da[Similar Products]

integrin, beta 4

integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit

Integrin beta-4

ITB4_HUMAN

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cell surface; hemidesmosome; leading edge; plasma membrane; basal plasma membrane; basement membrane; integrin complex; receptor complex

Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity

Biological Process: integrin-mediated signaling pathway; skin development; hemidesmosome assembly; extracellular matrix organization and biogenesis; filopodium formation; gut development; cell-matrix adhesion; cell motility involved in cell locomotion; response to wounding; autophagy; mesodermal cell differentiation; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia

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