Product Name
JAG1, cDNA Clone
Full Product Name
JAG1 cDNA Clone
Product Gene Name
JAG1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcgttccc cacggacgcg cggccggtcc gggcgccccc taagcctcct gctcgccctg ctctgtgccc tgcgagccaa ggtgtgtggg gcctcgggtc agttcgagtt ggagatcctg tccatgcaga acgtgaacgg ggagctgcag aacgggaact gctgcggcgg cgcccggaac ccgggagacc gcaagtgcac ccgcgacgag tgtgacacat acttcaaagt gtgcctcaag gagtatcagt cccgcgtcac ggccgggggg ccctgcagct tcggctcagg gtccacgcct gtcatcgggg gcaacacctt caacctcaag gccagccgcg gcaacgaccg caaccgcatc gtgctgcctt tcagtttcgc ctggccgagg tcctatacgt tgcttgtgga ggcgtgggat tccagtaatg acaccgttca acctgacagt attattgaaa aggcttctca ctcgggcatg atcaacccca gccggcagtg gcagacgctg aagcagaaca cgggcgttgc ccactttgag tatcagatcc gcgtgacctg tgatgactac tactatggct ttggctgcaa taagttctgc cgccccagag atgacttctt tggacactat gcctgtgacc agaatggcaa caaaacttgc atggaaggct ggatgggccc cgaatgtaac agagctattt gccgacaagg ctgcagtcct aagcatgggt cttgcaaact cccaggtgac tgcaggtgcc agtatggctg gcaaggcctg tactgtgata agtgcatccc acacccggga tgcgtccacg gcatctgtaa tgagccctgg cagtgcctct gtgagaccaa ctggggcggc cagctctgtg acaaagatct caattactgt gggactcatc agccgtgtct caacggggga acttgtagca acacaggccc tgacaaatat cagtgttcct gccctgaggg gtattcagga cccaactgtg aaattgctga gcacgcctgc ctctctgatc cctgtcacaa cagaggcagc tgtaaggaga cctccctggg ctttgagtgt gagtgttccc caggctggac cggccccaca tgctctacaa acattgatga ctgttctcct aataactgtt cccacggggg cacctgccag gacctggtta acggatttaa gtgtgtgtgc cccccacagt ggactgggaa aacgtgccag ttagatgcaa atgaatgtga ggccaaacct tgtgtaaacg ccaaatcctg taagaatctc attgccagct actactgcga ctgtcttccc ggctggatgg gtcagaattg tgacataaat attaatgact gccttggcca gtgtcagaat gacgcctcct gtcgggattt ggttaatggt tatcgctgta tctgtccacc tggctatgca ggcgatcact gtgagagaga catcgatgaa tgtgccagca acccctgttt gaatgggggt cactgtcaga atgaaatcaa cagattccag tgtctgtgtc ccactggttt ctctggaaac ctctgtcagc tggacatcga ttattgtgag cctaatccct gccagaacgg tgcccagtgc tacaaccgtg ccagtgacta tttctgcaag tgccccgagg actatgaggg caagaactgc tcacacctga aagaccactg ccgcacgacc ccctgtgaag tgattgacag ctgcacagtg gccatggctt ccaacgacac acctgaaggg gtgcggtata tttcctccaa cgtctgtggt cctcacggga agtgcaagag tcagtcggga ggcaaattca cctgtgactg taacaaaggc ttcacgggaa catactgcca tgaaaatatt aatgactgtg agagcaaccc ttgtagaaac ggtggcactt gcatcgatgg tgtcaactcc tacaagtgca tctgtagtga cggctgggag ggggcctact gtgaaaccaa tattaatgac tgcagccaga acccctgcca caatgggggc acgtgtcgcg acctggtcaa tgacttctac tgtgactgta aaaatgggtg gaaaggaaag acctgccact cacgtgacag tcagtgtgat gaggccacgt gcaacaacgg tggcacctgc tatgatgagg gggatgcttt taagtgcatg tgtcctggcg gctgggaagg aacaacctgt aacatagccc gaaacagtag ctgcctgccc aacccctgcc ataatggggg cacatgtgtg gtcaacggcg agtcctttac gtgcgtctgc aaggaaggct gggaggggcc catctgtgct cagaatacca atgactgcag ccctcatccc tgttacaaca gcggcacctg tgtggatgga gacaactggt accggtgcga atgtgccccg ggttttgctg ggcccgactg cagaataaac atcaatgaat gccagtcttc accttgtgcc tttggagcga cctgtgtgga tgagatcaat ggctaccggt gtgtctgccc tccagggcac agtggtgcca agtgccagga agtttcaggg agaccttgca tcaccatggg gagtgtgata ccagatgggg ccaaatggga tgatgactgt aatacctgcc agtgcctgaa tggacggatc gcctgctcaa aggtctggtg tggccctcga ccttgcctgc tccacaaagg gcacagcgag tgccccagcg ggcagagctg catccccatc ctggacgacc agtgcttcgt ccacccctgc actggtgtgg gcgagtgtcg gtcttccagt ctccagccgg tgaagacaaa gtgcacctct gactcctatt accaggataa ctgtgcgaac atcacattta cctttaacaa ggagatgatg tcaccaggtc ttactacgga gcacatttgc agtgaattga ggaatttgaa tattttgaag aatgtttccg ctgaatattc aatctacatc gcttgcgagc cttccccttc agcgaacaat gaaatacatg tggccatttc tgctgaagat atacgggatg atgggaaccc gatcaaggaa atcactgaca aaataatcga tcttgttagt aaacgtgatg gaaacagctc gctgattgct gccgttgcag aagtaagagt tcagaggcgg cctctgaaga acagaacaga tttccttgtt cccttgctga gctctgtctt aactgtggct tggatctgtt gcttggtgac ggccttctac tggtgcctgc ggaagcggcg gaagccgggc agccacacac actcagcctc tgaggacaac accaccaaca acgtgcggga gcagctgaac cagatcaaaa accccattga gaaacatggg gccaacacgg tccccatcaa ggattacgag aacaagaact ccaaaatgtc taaaataagg acacacaatt ctgaagtaga agaggacgac atggacaaac accagcagaa agcccggttt gccaagcagc cggcgtacac gctggtagac agagaagaga agccccccaa cggcacgccg acaaaacacc caaactggac aaacaaacag gacaacagag acttggaaag tgcccagagc ttaaaccgaa tggagtacat cgtatag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of JAG1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.
NCBI Accession #
BC126205
[Other Products]
UniProt Secondary Accession #
O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9[Other Products]
UniProt Related Accession #
P78504[Other Products]
Molecular Weight
116,579 Da
NCBI Official Full Name
Homo sapiens jagged 1 (Alagille syndrome), mRNA
NCBI Official Synonym Full Names
jagged 1
NCBI Official Symbol
JAG1 [Similar Products]
NCBI Official Synonym Symbols
AGS; AHD; AWS; HJ1; CD339; JAGL1
[Similar Products]
NCBI Protein Information
protein jagged-1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
Protein Family
Protein jagged
UniProt Gene Name
JAG1 [Similar Products]
UniProt Synonym Gene Names
JAGL1; Jagged1; hJ1 [Similar Products]
UniProt Entry Name
JAG1_HUMAN
NCBI Summary for JAG1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
UniProt Comments for JAG1
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in ***** and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p12.1-p11.23
Cellular Component: adherens junction; apical plasma membrane; membrane; plasma membrane
Molecular Function: Notch binding; protein binding
Biological Process: Notch receptor processing; Notch signaling pathway; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; T cell mediated immunity
Disease: Alagille Syndrome 1; Tetralogy Of Fallot
Research Articles on JAG1
1. DLL4 and JAG1 may have opposing effects on tumor angiogenesis in glioblastoma.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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