Full Product Name
IFT88 Antibody: HRP
Product Synonym Names
Rabbit Anti-Human IFT88 Polyclonal; D13S1056E Antibody; TPR repeat protein 10 Antibody; Tetratricopeptide repeat domain 10 Antibody; Ift88 Antibody; Recessive polycystic kidney disease protein Tg737 homolog Antibody; IFT88_HUMAN Antibody; Polaris homolog Antibody; Probe hTg737 (polycystic kidney disease; autosomal recessive) Antibody; TG737 Antibody; TTC10 Antibody; DAF19 Antibody; IFT88 Antibody; hTg737 Antibody; Intraflagellar transport 88 homolog Antibody; MGC26259 Antibody; Tetratricopeptide repeat protein 10 Antibody; Intraflagellar transport protein 88 homolog Antibody; RP11-172H24.2 Antibody
Product Gene Name
anti-IFT88 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: IFT88 (MBS809976)
HRP Conjugated Antibody: IFT88 (MBS809989)
Matching Pairs
Unconjugated Antibody: N/A (MBS809989)
HRP Conjugated Antibody: IFT88 (MBS809989)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13099
Species Reactivity
Human; Mouse
Specificity
Detects ~94 kDa.
Purity/Purification
Peptide Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthetic peptide from the mid to C-terminal of Human IFT88 (aa. 674-686)
Cellular Localization
Cytoplasm; Cytoskeleton; Microtubule Organizing Center; Centrosome; Centriole; Cytoplasm; Cytoskeleton; Cilium Basal Body
Storage Buffer
PBS, 50% glycerol, 0.09% sodium azide
Tissue Specificity
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-IFT88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IFT88 antibody
Antibodies; Cell Signaling; Epigenetics and Nuclear Signaling; DNA/RNA; Translation
Applications Tested/Suitable for anti-IFT88 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-IFT88 antibody
WB: 1:1000
ICC/IF: 1:100
Western Blot (WB) of anti-IFT88 antibody
Western blot analysis of Human Lung carcinoma epithelial cell line (A549) lysate showing detection of 94.3 kDa IFT88 protein using Rabbit Anti-IFT88 Polyclonal Antibody (SPC-679). Lane 1: Molecular Weight Ladder (MW). Lane 2: Human A549 cell lysates. Load: 15 ug. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-IFT88 Polyclonal Antibody (SPC-679) at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 94.3 kDa. Other Band(s): 45 kDa.
NCBI/Uniprot data below describe general gene information for IFT88. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001305420.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001318491.1
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UniProt Primary Accession #
Q13099
[Other Products]
UniProt Secondary Accession #
Q5SZJ6; Q8N719; A2A491; B4DUS2[Other Products]
UniProt Related Accession #
Q13099[Other Products]
Molecular Weight
92,381 Da
NCBI Official Full Name
intraflagellar transport protein 88 homolog isoform 3
NCBI Official Synonym Full Names
intraflagellar transport 88
NCBI Official Symbol
IFT88 [Similar Products]
NCBI Official Synonym Symbols
DAF19; TG737; TTC10; hTg737; D13S1056E
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NCBI Protein Information
intraflagellar transport protein 88 homolog
UniProt Protein Name
Intraflagellar transport protein 88 homolog
UniProt Synonym Protein Names
Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10
Protein Family
Intraflagellar transport protein
UniProt Gene Name
IFT88 [Similar Products]
UniProt Synonym Gene Names
TG737; TTC10; TPR repeat protein 10 [Similar Products]
NCBI Summary for IFT88
This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]
UniProt Comments for IFT88
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Research Articles on IFT88
1. multivariate Cox regression analyses demonstrated that Tg737 expression was an independent factor for predicting the overall survival of hepatocellular carcinoma patients
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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