Product Name
JAG1, Blocking Peptide
Full Product Name
JAG1 Peptide
Product Synonym Names
Jagged 1; AGS; AHD; AWS; CD339; HJ1; JAGL1 ; jagged 1
Product Gene Name
JAG1 blocking peptide
[Similar Products]
JAG1 peptide (MBS153791) is used for blocking the activity of JAG1 antibody (MBS153705)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P78504
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
19 amino acid peptide near the carboxy terminus of human JAG1.
Preparation and Storage
Store JAG1 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of JAG1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for JAG1 blocking peptide
Blocking (BL)
Application Notes for JAG1 blocking peptide
JAG1 peptide is used for blocking the activity of JAG1 antibody.
NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000205
[Other Products]
NCBI GenBank Nucleotide #
NM_000214.2
[Other Products]
UniProt Primary Accession #
P78504
[Other Products]
UniProt Secondary Accession #
O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9[Other Products]
UniProt Related Accession #
P78504[Other Products]
Molecular Weight
116,579 Da
NCBI Official Full Name
protein jagged-1
NCBI Official Synonym Full Names
jagged 1
NCBI Official Symbol
JAG1 [Similar Products]
NCBI Official Synonym Symbols
AGS; AHD; AWS; HJ1; CD339; JAGL1
[Similar Products]
NCBI Protein Information
protein jagged-1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
Protein Family
Protein jagged
UniProt Gene Name
JAG1 [Similar Products]
UniProt Synonym Gene Names
JAGL1; Jagged1; hJ1 [Similar Products]
UniProt Entry Name
JAG1_HUMAN
NCBI Summary for JAG1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
UniProt Comments for JAG1
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in ***** and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p12.1-p11.23
Cellular Component: membrane; integral to plasma membrane; apical part of cell; plasma membrane; extracellular region
Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activity
Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; angiogenesis; positive regulation of Notch signaling pathway
Disease: Tetralogy Of Fallot; Alagille Syndrome 1
Research Articles on JAG1
1. High cytoplasmic Jagged1 expression is associated with laryngeal cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
