Atonal Homolog 1 (ATOH1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ATOH1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9355400 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Atonal Homolog 1 (ATOH1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATOH1. The ELISA analytical biochemical technique of the MBS9355400 kit is based on ATOH1 antibody-ATOH1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATOH1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATOH1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

38,160 Da

atonal bHLH transcription factor 1

protein atonal homolog 1

Protein atonal homolog 1

ATH1; BHLHA14; bHLHa14; hATH1  [Similar Products]

ATOH1_HUMAN

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: nucleus

Molecular Function: chromatin DNA binding; protein dimerization activity; transcription factor activity

Biological Process: auditory receptor cell fate determination; auditory receptor cell fate specification; axon guidance; central nervous system development; cerebral cortex development; inner ear morphogenesis; negative regulation of apoptosis; neuron migration; Notch signaling pathway; positive regulation of auditory receptor cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

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