IFT88, Polyclonal Antibody

Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; IFT88; TG737; TTC10

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This IFT88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 791-820 amino acids from the C-terminal region of human IFT88.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-IFT88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the tetratrico peptide
repeat (TPR) family. Mutations of a similar gene in mouse can cause
polycystic kidney disease. Two transcript variants encoding
distinct isoforms have been identified for this gene. [provided by
RefSeq].

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

WB~~1:1000

IFT88 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the IFT88 antibody detected the IFT88 protein (arrow).

IFT88 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the IFT88 antibody detected the IFT88 protein (arrow).

IFT88 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IFT88 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Confocal immunofluorescent analysis of IFT88 Antibody (C-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

94270

intraflagellar transport 88

intraflagellar transport protein 88 homolog

Intraflagellar transport protein 88 homolog

TG737; TTC10; TPR repeat protein 10  [Similar Products]

IFT88_HUMAN

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

TTC10: Involved in primary cilium biogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 13q12.1

Cellular Component: centriole; apical part of cell; motile primary cilium; photoreceptor connecting cilium; acrosomal membrane; cilium

Molecular Function: kinesin binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; epidermis development; regulation of fat cell differentiation; spinal cord dorsal/ventral patterning; palate development; cardiac muscle cell differentiation; cytoplasmic microtubule organization and biogenesis; anterior/posterior pattern formation; spermatid nuclear elongation; protein localization; pancreas development; kidney development; regulation of odontogenesis of dentine-containing teeth; negative regulation of epithelial cell proliferation; Notch signaling pathway; smoothened signaling pathway; organelle organization and biogenesis; liver development; forebrain morphogenesis; telencephalon development; inner ear receptor stereocilium organization and biogenesis; eye development; sperm axoneme assembly; embryonic digit morphogenesis; determination of left/right symmetry; regulation of smoothened signaling pathway

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Robert, A., et al. J. Cell. Sci. 120 (PT 4), 628-637 (2007) :
Khanna, H., et al. J. Biol. Chem. 280(39):33580-33587(2005)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)

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