Full Product Name
Bid Antibody
Product Synonym Names
TS; TMS; HST422
Product Gene Name
anti-Bid antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04818
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant Protein of human TYMS
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-Bid antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Bid antibody
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
Product Categories/Family for anti-Bid antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-Bid antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-Bid antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:20-1:50
Western Blot (WB) of anti-Bid antibody
Western blot analysis of extracts of HeLacellline, using TYMS antibody.
NCBI/Uniprot data below describe general gene information for Bid. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001062.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001071.2
[Other Products]
UniProt Primary Accession #
P04818
[Other Products]
UniProt Secondary Accession #
Q8WYK3; Q8WYK4[Other Products]
UniProt Related Accession #
P04818[Other Products]
NCBI Official Full Name
thymidylate synthase
NCBI Official Synonym Full Names
thymidylate synthetase
NCBI Official Symbol
TYMS [Similar Products]
NCBI Official Synonym Symbols
TS; TMS; HST422
[Similar Products]
NCBI Protein Information
thymidylate synthase
UniProt Protein Name
Thymidylate synthase
Protein Family
Bidirectional sugar transporter
UniProt Gene Name
TYMS [Similar Products]
UniProt Synonym Gene Names
TS; TS; TSase [Similar Products]
NCBI Summary for Bid
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
UniProt Comments for Bid
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Research Articles on Bid
1. Two SNPs (rs523230 and rs9967368) in TYMS gene were significantly associated with the overall survival of HCC patients.
Precautions
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Disclaimer
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