APOL1 / Apolipoprotein L, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human APOL1 / Apolipoprotein L; Human APOL1 / Apolipoprotein L; Apolipoprotein L-I; APOL-I; Apolipoprotein L; 1; APOL; Apolipoprotein L; FSGS4; APO-L; Apolipoprotein L1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

APOL1 Antibodyantibody detects endogenous levels of APOL1.

Immunoaffinity purified

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C.

Small volumes of anti-APOL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

APOL1 Antibody, Apolipoprotein L-I Antibody, APOL-I Antibody, Apolipoprotein L, 1 Antibody, APOL Antibody, Apolipoprotein L Antibody, FSGS4 Antibody, APO-L Antibody, Apolipoprotein L1 Antibody Description: APOL1 / Apolipoprotein L is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

ELISA (1:10000)
IHC-P (5 ug/ml)
WB (1:500 - 1:1000)

Anti-APOL1 / Apolipoprotein L antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-APOL1 / Apolipoprotein L antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Western blot of the lysates from K562 cells using APOL1 antibody.

42,158 Da

apolipoprotein L1

apolipoprotein L1

Apolipoprotein L1

APOL; Apo-L; ApoL; ApoL-I  [Similar Products]

APOL1_HUMAN

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Channel, chloride; Secreted, signal peptide; Lipid-binding

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular region; extracellular space; intrinsic to membrane

Molecular Function: chloride channel activity; lipid binding; protein binding

Biological Process: cholesterol metabolic process; cytolysis; innate immune response; killing of cells of another organism; lipid transport; lipoprotein metabolic process; receptor-mediated endocytosis

Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To

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