Product Name
Slitrk1, Blocking Peptide
Full Product Name
Slitrk1 Peptide
Product Synonym Names
TTM; LRRC12; KIAA1910; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12; SLIT and NTRK-like family, member 1
Product Gene Name
SLITRK1 blocking peptide
[Similar Products]
Slitrk1 peptide (MBS151862) is used for blocking the activity of Slitrk1 antibody (MBS150177)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96PX8
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
18 amino acids near the center of human Slitrk1.
Preparation and Storage
Store Slitrk1 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of SLITRK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for SLITRK1 blocking peptide
Blocking (BL)
Application Notes for SLITRK1 blocking peptide
Slitrk1 peptide is used for blocking the activity of Slitrk1 antibody.
NCBI/Uniprot data below describe general gene information for SLITRK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443142
[Other Products]
NCBI GenBank Nucleotide #
NM_052910.2
[Other Products]
UniProt Primary Accession #
Q96PX8
[Other Products]
UniProt Secondary Accession #
Q5U5I6; Q96SF9[Other Products]
UniProt Related Accession #
Q96PX8[Other Products]
Molecular Weight
77,735 Da
NCBI Official Full Name
SLIT and NTRK-like protein 1
NCBI Official Synonym Full Names
SLIT and NTRK-like family, member 1
NCBI Official Symbol
SLITRK1 [Similar Products]
NCBI Official Synonym Symbols
TTM; LRRC12
[Similar Products]
NCBI Protein Information
SLIT and NTRK-like protein 1; slit and trk like gene 1; leucine-rich repeat-containing protein 12
UniProt Protein Name
SLIT and NTRK-like protein 1
UniProt Synonym Protein Names
Leucine-rich repeat-containing protein 12
Protein Family
SLIT and NTRK-like protein
UniProt Gene Name
SLITRK1 [Similar Products]
UniProt Synonym Gene Names
KIAA1910; LRRC12 [Similar Products]
UniProt Entry Name
SLIK1_HUMAN
NCBI Summary for SLITRK1
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for SLITRK1
SLITRK1: Enhances neuronal dendrite outgrowth. Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM). It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Belongs to the SLITRK family.
Protein type: Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q31.1
Cellular Component: integral to membrane
Biological Process: homeostatic process; axonogenesis; ***** behavior; multicellular organism growth
Disease: Gilles De La Tourette Syndrome; Trichotillomania
Research Articles on SLITRK1
1. the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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