Product Name
Vitamin K epoxide reductase complex subunit 1 (Vkorc1), Recombinant Protein
Full Product Name
Recombinant Mouse Vitamin K epoxide reductase complex subunit 1 (Vkorc1)
Product Gene Name
Vkorc1 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-161aa; full length protein
Sequence
MGTTWRSPGL VRLALCLAGL ALSLYALHVK AARARDENYR ALCDVGTAIS CSRVFSSRWG RGFGLVEHML GADSVLNQSN SIFGCLFYTL QLLLGCLRGR WASILLVLSS LVSVAGSVYL AWILFFVLYD FCIVCITTYA INVGLMLLSF QKVPEHKTKK H
3D Structure
ModBase 3D Structure for Q9CRC0
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Vkorc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Vkorc1 recombinant protein
Transmembrane Protein
Application Notes for Vkorc1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Vkorc1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848715.1
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NCBI GenBank Nucleotide #
NM_178600.2
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UniProt Primary Accession #
Q9CRC0
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UniProt Related Accession #
Q9CRC0[Other Products]
Molecular Weight
17,768 Da
NCBI Official Full Name
vitamin K epoxide reductase complex subunit 1
NCBI Official Synonym Full Names
vitamin K epoxide reductase complex, subunit 1
NCBI Official Symbol
Vkorc1 [Similar Products]
NCBI Official Synonym Symbols
D7Wsu86e
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NCBI Protein Information
vitamin K epoxide reductase complex subunit 1
UniProt Protein Name
Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names
Vitamin K1 2,3-epoxide reductase subunit 1
Protein Family
Vitamin K epoxide reductase complex
UniProt Gene Name
Vkorc1 [Similar Products]
UniProt Entry Name
VKOR1_MOUSE
NCBI Summary for Vkorc1
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]
UniProt Comments for Vkorc1
VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; EC 1.1.4.1; Oxidoreductase; Membrane protein, integral
Cellular Component: endoplasmic reticulum; integral to membrane; intracellular membrane-bound organelle; membrane
Molecular Function: oxidoreductase activity; quinone binding; vitamin-K-epoxide reductase (warfarin-insensitive) activity; vitamin-K-epoxide reductase (warfarin-sensitive) activity
Biological Process: blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation; positive regulation of coagulation; regulation of blood coagulation; response to antibiotic; response to organic cyclic substance; response to organic nitrogen; vitamin K biosynthetic process; vitamin K metabolic process
Research Articles on Vkorc1
1. quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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