Connexin 30.3, Monoclonal Antibody

Anti -Connexin 30.3 (Gap Junction beta-4 Protein, Connexin-30.3, Cx30.3, GJB4)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000070.6 (127351086..127354081, complement). Location: 4 D1-D3; 4 61.51 cM

Monoclonal

IgG2a,k

1E3-1C12

Mouse

Recognizes human GJB4.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-Gjb4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

Antibodies; Abs to Connexin, Junction Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.

30,389 Da[Similar Products]

gap junction protein, beta 4

gap junction beta-4 protein; connexin-30.3; gap junction membrane channel protein beta 4

Gap junction beta-4 protein

Cxn-30.3; Cx30.3  [Similar Products]

CXB4_MOUSE

GJB4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB4 are a cause of erythrokeratodermia variabilis (EKV). EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. Belongs to the connexin family. Beta-type (group I) subfamily.

Protein type: Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass

Cellular Component: connexon complex; membrane; integral to membrane; plasma membrane; gap junction; cell junction

Biological Process: olfactory behavior; sensory perception of smell; cell communication

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