Full Product Name
CABC1 Polyclonal Antibody
Product Gene Name
anti-CABC1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NI60
Other Notes
Small volumes of anti-CABC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CABC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064632.2
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NCBI GenBank Nucleotide #
NM_020247.4
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UniProt Primary Accession #
Q8NI60
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UniProt Secondary Accession #
Q5T7A5; Q63HK0; Q8NCJ6; Q9HBQ1; Q9NQ67[Other Products]
UniProt Related Accession #
Q8NI60[Other Products]
Molecular Weight
42,537 Da
NCBI Official Full Name
atypical kinase COQ8A, mitochondrial
NCBI Official Synonym Full Names
coenzyme Q8A
NCBI Official Symbol
COQ8A [Similar Products]
NCBI Official Synonym Symbols
COQ8; ADCK3; ARCA2; CABC1; SCAR9; COQ10D4
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NCBI Protein Information
atypical kinase COQ8A, mitochondrial
UniProt Protein Name
Atypical kinase COQ8A, mitochondrial
UniProt Synonym Protein Names
Chaperone activity of bc1 complex-like
UniProt Gene Name
COQ8A [Similar Products]
UniProt Synonym Gene Names
Chaperone-ABC1-like [Similar Products]
NCBI Summary for CABC1
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CABC1
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
Research Articles on CABC1
1. Loss of COQ8a results in cerebellar ataxia and coenzyme Q deficiency.
Precautions
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Disclaimer
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