Product Name
CABC1 (ADCK3), Polyclonal Antibody
Full Product Name
CABC1 (Chaperone-activity of bc1 Complex-like, Mitochondrial, Chaperone-ABC1-like, aarF Domain-containing Protein Kinase 3, ADCK3, MGC4849, PP265)
Product Synonym Names
Anti -CABC1 (Chaperone-activity of bc1 Complex-like, Mitochondrial, Chaperone-ABC1-like, aarF Domain-containing Protein Kinase 3, ADCK3, MGC4849, PP265)
Product Gene Name
anti-ADCK3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ IGMFLGKVQG QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD QSAPPSLGHA HSEGPAPAYV ASGPFREAGF PGQASSPLGR ANGRLFANPR DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK ARQAKARPEN KQHKQTLSEH ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE DPSGKKAVLG SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK GGREVAMKIQ YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR ELALECDYQR EAACARKFRD LLKGHPFFYV PEIVDELCSP HVLTTELVSG FPLDQAEGLS QEIRNEICYN ILVLCLRELF EFHFMQTDPN WSNFFYDPQQ HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK SIEMKFLTGY EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ
Chromosome Location
Chromosome: 1; NC_000001.10 (227084589..227175246). Location: 1q42.13
3D Structure
ModBase 3D Structure for Q8NI60
Specificity
Recognizes human CABC1.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human CABC1, aa1-647 (NP_064632.2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADCK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADCK3 antibody
May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
Product Categories/Family for anti-ADCK3 antibody
Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-ADCK3 antibody
Western Blot (WB)
Application Notes for anti-ADCK3 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for ADCK3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064632.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020247.4
[Other Products]
UniProt Primary Accession #
Q8NI60
[Other Products]
UniProt Secondary Accession #
Q5T7A5; Q63HK0; Q8NCJ6; Q9HBQ1; Q9NQ67[Other Products]
UniProt Related Accession #
Q8NI60[Other Products]
Molecular Weight
71,950 Da[Similar Products]
NCBI Official Full Name
chaperone activity of bc1 complex-like, mitochondrial
NCBI Official Synonym Full Names
aarF domain containing kinase 3
NCBI Official Symbol
ADCK3 [Similar Products]
NCBI Official Synonym Symbols
COQ8; ARCA2; CABC1; SCAR9; COQ10D4
[Similar Products]
NCBI Protein Information
chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog
UniProt Protein Name
Chaperone activity of bc1 complex-like, mitochondrial
UniProt Synonym Protein Names
aarF domain-containing protein kinase 3
UniProt Gene Name
ADCK3 [Similar Products]
UniProt Synonym Gene Names
CABC1; Chaperone-ABC1-like [Similar Products]
UniProt Entry Name
ADCK3_HUMAN
NCBI Summary for ADCK3
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ADCK3
Function: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
Subcellular location: Mitochondrion Ref.1.
Tissue specificity: Ubiquitously expressed with a relatively greater abundance in heart and skeletal muscle.
Induction: By p53/TP53.
Involvement in disease: Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11
Sequence similarities: Belongs to the protein kinase superfamily. ADCK protein kinase family.Contains 1 protein kinase domain.
Caution: It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Research Articles on ADCK3
1. These observations highlight the importance of screening for a potentially treatable cause, CABC1/ADCK3 mutations
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
