Full Product Name
TYMS Antibody
Product Synonym Names
TYMS; HST422; Thymidylate synthetase; TMS; TS; Thymidylate synthase; Tsase
Product Gene Name
anti-TYMS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04818
Specificity
TYMS Antibody detects endogenous levels of total TYMS
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human TYMS
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-TYMS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TYMS antibody
Total protein Ab
Applications Tested/Suitable for anti-TYMS antibody
Western Blot (WB)
Application Notes for anti-TYMS antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-TYMS antibody
Western blot analysis TYMS using COS7 whole cell lysates
NCBI/Uniprot data below describe general gene information for TYMS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001062.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001071.2
[Other Products]
UniProt Primary Accession #
P04818
[Other Products]
UniProt Secondary Accession #
Q8WYK3; Q8WYK4[Other Products]
UniProt Related Accession #
P04818[Other Products]
Molecular Weight
26,140 Da
NCBI Official Full Name
thymidylate synthase
NCBI Official Synonym Full Names
thymidylate synthetase
NCBI Official Symbol
TYMS [Similar Products]
NCBI Official Synonym Symbols
TS; TMS; HST422
[Similar Products]
NCBI Protein Information
thymidylate synthase
UniProt Protein Name
Thymidylate synthase
Protein Family
TYMS opposite strand protein
UniProt Gene Name
TYMS [Similar Products]
UniProt Synonym Gene Names
TS; TS; TSase [Similar Products]
UniProt Entry Name
TYSY_HUMAN
NCBI Summary for TYMS
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
UniProt Comments for TYMS
TYMS: an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 18p11.32
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus
Molecular Function: folic acid binding; thymidylate synthase activity
Biological Process: dTMP biosynthetic process; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; pyrimidine nucleoside biosynthetic process; response to organophosphorus
Research Articles on TYMS
1. Our findings emphasize the pivotal relevance of RNAi as an effective tool for increasing the therapeutic efficacy of PMX, a cornerstone in the treatment regimens of Malignant mesothelioma thereby, raising the possibility for the development of a novel therapeutic strategy, combination therapy of TS-shRNA and PMX, that can surpass many of the currently applied, but less effective, therapeutic regimens against lethal MPM.
Precautions
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