Product Name
CHRNA4, Polyclonal Antibody
Full Product Name
Human CHRNA4 Polyclonal Antibody
Product Synonym Names
NACRA4
Product Gene Name
anti-CHRNA4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human CHRNA4 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-CHRNA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHRNA4 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CHRNA4. It may not necessarily be applicable to this product.
UniProt Related Accession #
P43681[Other Products]
NCBI Official Full Name
CHRNA4 protein
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 4 subunit
NCBI Official Symbol
CHRNA4 [Similar Products]
NCBI Official Synonym Symbols
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
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NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-4
Protein Family
Neuronal acetylcholine receptor
NCBI Summary for CHRNA4
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Research Articles on CHRNA4
1. cryoelectron microscopy and the structural principles of distinct assemblies of the human alpha4beta2 nicotinic receptor
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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