Full Product Name
PVRL4 Antibody
Product Gene Name
anti-PVRL4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96NY8
Specificity
PVRL4 Antibody detects endogenous levels of total PVRL4 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human PVRL4.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-PVRL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PVRL4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PVRL4 antibody
WB: 1:500~1:1000
ELISA: 1:1000
Western Blot (WB) of anti-PVRL4 antibody
Western blot analysis of lysates from NIH/3T3 cells, using PVRL4 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for PVRL4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_112178.2
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NCBI GenBank Nucleotide #
NM_030916.2
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UniProt Primary Accession #
Q96NY8
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UniProt Secondary Accession #
Q96K15; B4DQW3[Other Products]
UniProt Related Accession #
Q96NY8[Other Products]
NCBI Official Full Name
nectin-4
NCBI Official Synonym Full Names
nectin cell adhesion molecule 4
NCBI Official Symbol
NECTIN4 [Similar Products]
NCBI Official Synonym Symbols
LNIR; PRR4; EDSS1; PVRL4; nectin-4
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NCBI Protein Information
nectin-4
UniProt Protein Name
Nectin-4
UniProt Synonym Protein Names
Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4
UniProt Gene Name
NECTIN4 [Similar Products]
NCBI Summary for PVRL4
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
UniProt Comments for PVRL4
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.
Research Articles on PVRL4
1. Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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