Full Product Name
PIBF1 (Progesterone-induced Blocking Factor 1, PIBF, Chromosome 13 Open Reading Frame 24, C13orf24, KIAA1008, Progesterone Immunomodulatory Binding Factor 1, RP11-505F3.1)
Product Synonym Names
Anti -PIBF1 (Progesterone-induced Blocking Factor 1, PIBF, Chromosome 13 Open Reading Frame 24, C13orf24, KIAA1008, Progesterone Immunomodulatory Binding Factor 1, RP11-505F3.1)
Product Gene Name
anti-PIBF1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL AFQQKDASKY QELMKQEMET ILLRQKQLEE TNLQLREKAG DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP EYVSVRFYEL VNPLRKEICE LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE SKKAREEMYE KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR EMYERENRNL REARDNAVAE KERAVMAEKD ALEKHDQLLD RYRELQLSTE SKVTEFLHQS KLKSFESERV QLLQEETARN LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL EKDVSNLNKE KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS ENSLLLTKTE PKHVTENQKS KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS KKQKMKT
Chromosome Location
Chromosome: 13; NC_000013.10 (73356202..73590592). Location: 13q22.1
3D Structure
ModBase 3D Structure for Q8WXW3
Specificity
Recognizes human PIBF1.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full-length human PIBF1, aa1-757 (NP_006337.2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-PIBF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PIBF1 antibody
PIBF (progesterone-induced blocking factor 1) is synthesized during pregnancy in response to progesterone by progesterone receptor-positive T lymphocytes (mostly gamma-delta T cells). In the presence of PIBF, natural killer (NK) cells inhibit the release of perforin from storage granules and, therefore, fail to lyse target cells. In humans, the amount of cells that express PIBF is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. PIBF has a predicted 89kD molecular mass; the full-length PIBF is associated with the nucleus, whereas secretion of shorter forms, such a 34kD protein is induced by activation of the cell. Research suggests that PIBF functions as a transcription factor in its full-length form, while smaller forms may act as cytokines.
Product Categories/Family for anti-PIBF1 antibody
Antibodies; Abs to Hormones, Steroids
Applications Tested/Suitable for anti-PIBF1 antibody
Western Blot (WB)
Application Notes for anti-PIBF1 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for PIBF1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH41806.1
[Other Products]
UniProt Primary Accession #
Q8WXW3
[Other Products]
UniProt Secondary Accession #
O95664; Q6U9V2; Q6UG50; Q86V07; Q96SF4[Other Products]
UniProt Related Accession #
Q8WXW3[Other Products]
Molecular Weight
89,805 Da[Similar Products]
NCBI Official Full Name
PIBF1 protein
NCBI Official Synonym Full Names
progesterone immunomodulatory binding factor 1
NCBI Official Symbol
PIBF1 [Similar Products]
NCBI Official Synonym Symbols
PIBF; CEP90; C13orf24; RP11-505F3.1
[Similar Products]
NCBI Protein Information
progesterone-induced-blocking factor 1; progesterone-induced blocking factor 1
UniProt Protein Name
Progesterone-induced-blocking factor 1
Protein Family
Progesterone-induced-blocking factor
UniProt Gene Name
PIBF1 [Similar Products]
UniProt Synonym Gene Names
C13orf24; PIBF [Similar Products]
UniProt Entry Name
PIBF1_HUMAN
UniProt Comments for PIBF1
PIBF1: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 13q22.1
Cellular Component: centrosome
Molecular Function: protein binding
Research Articles on PIBF1
1. CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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