VKORC1, Polyclonal Antibody

3-epoxide reductase subunit 1; EDTP308; FLJ00289; IMAGE3455200; MGC2694; MST134; MST576; Phylloquinone epoxide reductase; Vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2; Vitamin K1 epoxide reductase (warfarin sensitive); VKCFD2; VKOR; VKORC1 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

0.65-0.70 ug/ul in antibody stabilization buffer (lot specific)

-20 degree C for long term storage

Small volumes of anti-VKORC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Vitamin K epoxide reductase complex subunit 1 Antibody
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2, 3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

Primary Antibodies; Cell Biology; VKORC1 Antibody

ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Confocal Microscopy||1:250
Dot Blot: 1:50,000
ELISA: 1:50,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:200
Western Blot: 1:500

17,783 Da

vitamin K epoxide reductase complex subunit 1

vitamin K epoxide reductase complex subunit 1

Vitamin K epoxide reductase complex subunit 1

VKOR1_RAT

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

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