Full Product Name
KERA, CT (KERA, SLRR2B, Keratocan, Keratan sulfate proteoglycan keratocan)
Product Synonym Names
Anti -KERA, CT (KERA, SLRR2B, Keratocan, Keratan sulfate proteoglycan keratocan)
Product Gene Name
anti-KERA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (91444268..91452131, complement). Location: 12q22
3D Structure
ModBase 3D Structure for O60938
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
KERA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human KERA.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-KERA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KERA antibody
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).
Product Categories/Family for anti-KERA antibody
Antibodies; Abs to Carbohydrates, Glycoproteins
Applications Tested/Suitable for anti-KERA antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KERA antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for KERA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_008966.1
[Other Products]
NCBI GenBank Nucleotide #
NM_007035.3
[Other Products]
UniProt Primary Accession #
O60938
[Other Products]
UniProt Related Accession #
O60938[Other Products]
Molecular Weight
40,509 Da[Similar Products]
NCBI Official Full Name
keratocan
NCBI Official Synonym Full Names
keratocan
NCBI Official Symbol
KERA [Similar Products]
NCBI Official Synonym Symbols
CNA2; SLRR2B
[Similar Products]
NCBI Protein Information
keratocan; KTN; keratan sulfate proteoglycan keratocan
UniProt Protein Name
Keratocan
UniProt Synonym Protein Names
Keratan sulfate proteoglycan keratocan
UniProt Gene Name
KERA [Similar Products]
UniProt Synonym Gene Names
SLRR2B; KTN [Similar Products]
UniProt Entry Name
KERA_HUMAN
NCBI Summary for KERA
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
UniProt Comments for KERA
KERA: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2). In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region
Biological Process: keratan sulfate metabolic process; visual perception; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; response to stimulus; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process
Disease: Cornea Plana 2
Research Articles on KERA
1. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
