Product Name
Histamine H2 Receptor (HRH2), Polyclonal Antibody
Full Product Name
Histamine H2 Receptor Polyclonal Antibody
Product Gene Name
anti-HRH2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P25021
Other Notes
Small volumes of anti-HRH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001124527.1
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NCBI GenBank Nucleotide #
NM_001131055.1
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UniProt Primary Accession #
P25021
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UniProt Secondary Accession #
Q14464; Q7Z5R9; B5BUP7[Other Products]
UniProt Related Accession #
P25021[Other Products]
Molecular Weight
44,541 Da[Similar Products]
NCBI Official Full Name
histamine H2 receptor
NCBI Official Synonym Full Names
histamine receptor H2
NCBI Official Symbol
HRH2 [Similar Products]
NCBI Official Synonym Symbols
H2R
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NCBI Protein Information
histamine H2 receptor
UniProt Protein Name
Histamine H2 receptor
UniProt Synonym Protein Names
Gastric receptor I
Protein Family
Histamine H2 receptor
UniProt Gene Name
HRH2 [Similar Products]
UniProt Synonym Gene Names
H2R; HH2R [Similar Products]
NCBI Summary for HRH2
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for HRH2
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway ().
Research Articles on HRH2
1. Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells
Precautions
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Disclaimer
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