Product Name
Histamine H2 receptor (HRH2), Recombinant Protein
Full Product Name
Recombinant Human Histamine H2 receptor (HRH2)
Product Synonym Names
Recombinant Histamine H2 receptor (HRH2); Histamine H2 receptor; H2R; HH2R; Gastric receptor I
Product Gene Name
HRH2 recombinant protein
[Similar Products]
Product Synonym Gene Name
HRH2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDR
Chromosome Location
Chromosome: 5; NC_000005.9 (175085040..175113245). Location: 5q35.2
3D Structure
ModBase 3D Structure for P25021
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HRH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001124527.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001131055.1
[Other Products]
UniProt Primary Accession #
P25021
[Other Products]
UniProt Secondary Accession #
Q14464; Q7Z5R9; B5BUP7[Other Products]
UniProt Related Accession #
P25021[Other Products]
Molecular Weight
40,098 Da[Similar Products]
NCBI Official Full Name
histamine H2 receptor isoform 1
NCBI Official Synonym Full Names
histamine receptor H2
NCBI Official Symbol
HRH2 [Similar Products]
NCBI Official Synonym Symbols
H2R
[Similar Products]
NCBI Protein Information
histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I
UniProt Protein Name
Histamine H2 receptor
UniProt Synonym Protein Names
Gastric receptor I
Protein Family
Histamine H2 receptor
UniProt Gene Name
HRH2 [Similar Products]
UniProt Synonym Gene Names
H2R; HH2R [Similar Products]
UniProt Entry Name
HRH2_HUMAN
NCBI Summary for HRH2
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for HRH2
H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: histamine receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; gland development; gastrin-induced gastric acid secretion; gut development; histamine-induced gastric acid secretion; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning; immune response; memory
Research Articles on HRH2
1. The results suggest that HRH2 -1018 GG homozygote is a risk factor for the severity of gastric mucosal atrophy under the influence of H. pylori infection, especially in older subjects.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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