Full Product Name
Rat Monoclonal Antibody to PKD1
Product Synonym Names
PC1; Mflj00285
Product Gene Name
anti-PKD1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Other Notes
Small volumes of anti-PKD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PKD1 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-PKD1 antibody
Western blot using Recombinant protein
NCBI/Uniprot data below describe general gene information for PKD1. It may not necessarily be applicable to this product.
NCBI Accession #
AGT98389.1
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UniProt Secondary Accession #
E9QJR6[Other Products]
UniProt Related Accession #
O08852[Other Products]
NCBI Official Full Name
PKD1, partial
NCBI Official Synonym Full Names
polycystin 1, transient receptor poteintial channel interacting
NCBI Official Symbol
Pkd1 [Similar Products]
NCBI Official Synonym Symbols
PC1; mFLJ00285
[Similar Products]
NCBI Protein Information
polycystin-1
UniProt Protein Name
Polycystin-1
UniProt Synonym Protein Names
Autosomal dominant polycystic kidney disease 1 protein homolog
Protein Family
Polycystin
UniProt Gene Name
Pkd1 [Similar Products]
UniProt Comments for PKD1
Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Research Articles on PKD1
1. PC1/3 deficiency was associated with increased expression of melanocortin receptors and PRCP (prolylcarboxypeptidase, a catabolic enzyme for alpha-melanocyte stimulating hormone (alphaMSH)), and reduced adrenocorticotropic hormone secretion. We conclude that the obesity accompanying PCSK1 deficiency may not be primarily due to alphaMSH deficiency.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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